Trends and Innovations in Biosensors for COVID-19 Mass Testing

被引:94
|
作者
Santiago, Ibon [1 ]
机构
[1] Tech Univ Munich, Phys Dept, Coulombwall 4a-II, D-85748 Garching, Germany
关键词
COVID-19; CRISPR diagnostics; immunoassays; isothermal amplification; molecular diagnostics;
D O I
10.1002/cbic.202000250
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Fast and widespread diagnosis is crucial to fighting against the outbreak of COVID-19. This work surveys the landscape of available and emerging biosensor technologies for COVID-19 testing. Molecular diagnostic assays based on quantitative reverse transcription polymerase chain reaction are used in most clinical laboratories. However, the COVID-19 pandemic has overwhelmed testing capacity and motivated the development of fast point-of-care tests and the adoption of isothermal DNA amplification. Antigenic and serological rapid tests based on lateral-flow immunoassays suffer from low sensitivity. Advanced digital systems enhance performance at the expense of speed and the need for large equipment. Emerging technologies, including CRISPR gene-editing tools, benefit from high sensitivity and specificity of molecular diagnostics and the easy use of lateral-flow assays. DNA sequencing and sample pooling strategies are highlighted to bring out the full capacity of the available biosensor technologies and accelerate mass testing.
引用
收藏
页码:2880 / 2889
页数:10
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