Ipilimumab-Induced Colitis on FDG PET/CT

被引：23
|
作者：
Lyall, Ashima [1 ]
Vargas, Herbert Alberto [1 ]
Carvajal, Richard D. [1 ]
Ulaner, Gary [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10065 USA
来源：
CLINICAL NUCLEAR MEDICINE | 2012年 / 37卷 / 06期
关键词：
ipilimumab; colitis; FDG; ANTI-CTLA-4; ANTIBODY; MELANOMA; CTLA-4;
D O I：
10.1097/RLU.0b013e318248549a
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
A 52-year-old woman with metastatic melanoma was treated with ipilimumab. After 2 cycles of treatment, she developed watery diarrhea, sweats, and chills. An FDG PET/CT study demonstrated new FDG-avid (maximum standardized uptake value 15.6) diffuse colonic wall thickening, suggestive of ipilimumab-induced colitis. The patient was treated with systemic steroids, with subsequent resolution of her symptoms. Based on the response to steroids, the diagnosis of ipilimumab-induced enterocolitis was made. Ipilimumab may cause several immune-mediated toxicities, the most common of which is enterocolitis. Physicians interpreting FDG PET/CT examinations of patients treated with ipilimumab should be aware of these FDG-avid immune-mediated toxicities. © 2012 by Lippincott Williams & Wilkins.
引用
收藏
页码：629 / 630
页数：2
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