Radiotherapy Complements Immune Checkpoint Blockade

被引：55
|
作者：
Ngiow, Shin Foong [1 ,2 ]
McArthur, Grant A. [3 ,4 ]
Smyth, Mark J. [1 ,2 ]
机构：
[1] QIMR Berghofer Med Res Inst, Immunol Canc & Infect Lab, Herston, Qld 4006, Australia
[2] Univ Queensland, Sch Med, Herston, Qld 4006, Australia
[3] Peter MacCallum Canc Ctr, Trescowthick Labs, Canc Therapeut Programs, East Melbourne, Vic 3002, Australia
[4] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3010, Australia
来源：
CANCER CELL | 2015年 / 27卷 / 04期
关键词：
CANCER; IMMUNOTHERAPY; IPILIMUMAB; RADIATION; MELANOMA; TUMORS; COMBINATION; THERAPY; PATIENT;
D O I：
10.1016/j.ccell.2015.03.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Adaptive immune resistance ablates effective anti-tumor immune responses. In a recent issue of Nature, Victor and colleagues describe that anti-PD-L1 combats adaptive immune resistance upon localized radiation plus anti-CTLA-4 therapy. The superior activity of radiation and dual immune checkpoint blockade is mediated by non-redundant immune mechanisms in cancer.
引用
收藏
页码：437 / 438
页数：2
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