Evaluation of patches for rotator cuff repair: A systematic review and meta-analysis based on animal studies

被引:10
|
作者
Yang, Jinwei [1 ,2 ]
Kang, Yuhao [3 ]
Zhao, Wanlu [4 ,5 ]
Jiang, Jia [3 ]
Jiang, Yanbiao [1 ]
Zhao, Bing [1 ]
Jiao, Mingyue [1 ]
Yuan, Bo [4 ,5 ]
Zhao, Jinzhong [3 ]
Ma, Bin [1 ,6 ]
机构
[1] Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China
[2] Gansu Prov Matern & ChildCare Hosp, Reprod Med Ctr, Lanzhou 730050, Peoples R China
[3] Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Sports Med, Shanghai 200233, Peoples R China
[4] Sichuan Univ, Coll Biomed Engn, Chengdu 610064, Peoples R China
[5] Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
[6] Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou 730000, Peoples R China
关键词
Rotator cuff patch; Animal model; Systematic review; Meta-analysis; Safety and effectiveness; SMALL-INTESTINE SUBMUCOSA; EXTRACELLULAR-MATRIX SCAFFOLDS; TISSUE-ENGINEERED TENDON; GELATIN HYDROGEL SHEETS; MESENCHYMAL STEM-CELLS; CORTICAL BONE-MATRIX; IN-VIVO; CARBON-FIBER; SURGICAL REPAIR; DERMAL PATCH;
D O I
10.1016/j.bioactmat.2021.08.016
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Based on the published animal studies, we systematically evaluated the outcomes of various materials for rotator cuff repair in animal models and the potentials of their clinical translation. 74 animal studies were finally included, of which naturally derived biomaterials were applied the most widely (50.0%), rats were the most commonly used animal model (47.0%), and autologous tissue demonstrated the best outcomes in all animal models. The biomechanical properties of naturally derived biomaterials (maximum failure load: WMD 18.68 [95%CI 7.71-29.66]; P = 0.001, and stiffness: WMD 1.30 [95%CI 0.01-2.60]; P = 0.048) was statistically significant in the rabbit model. The rabbit model showed better outcomes even though the injury was severer compared with the rat model.
引用
收藏
页码:474 / 491
页数:18
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