Expression of Tumor Necrosis Factor-α, Interleukin-1α, Interleukin-6 and Interleukin-10 in Chronic Otitis Media with Bone Osteolysis

被引：39
|
作者：
Kuczkowski, Jerzy [1 ]
Sakowicz-Burkiewicz, Monika [2 ]
Izycka-Swieszewska, Ewa [3 ]
Mikaszewski, Boguslaw [1 ]
Pawelczyk, Tadeusz [2 ]
机构：
[1] Med Acad Gdansk, Dept Otolaryngol, PL-80211 Gdansk, Poland
[2] Med Acad Gdansk, Dept Mol Med, PL-80211 Gdansk, Poland
[3] Med Acad Gdansk, Dept Pathomorphol, PL-80211 Gdansk, Poland
来源：
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 2011年 / 73卷 / 02期
关键词：
Chronic otitis media; Cholesteatoma; Bone osteolysis; Proinflammatory and immunomodulatory cytokines; MIDDLE-EAR CHOLESTEATOMA; GENE; RESORPTION; IL-1;
D O I：
10.1159/000323831
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
The purpose of this study was to evaluate the expression of proinflammatory and immunoregulatory cytokines in chronic otitis media. The expression levels of TNF-alpha, IL-1 alpha, IL-6 and IL-10 were determined by Western blot analysis of tissue samples obtained during ear surgery. The expression levels of TNF-alpha, IL-1 alpha and IL-6 in cholesteatoma tissues were substantially higher compared to those determined in the granulation tissue. The highest levels of TNF-alpha, IL-1 and IL-6 proteins were observed in patients with bone destruction. There were no significant differences in the expression of IL-10 levels in cholesteatoma and normal skin, but in the granulation tissue its level was substantially higher. The level of IL-10 in cholesteatoma tissues inversely correlated with the expression of proinflammatory cytokines, the degree of bone destruction and cholesteatoma invasion. Increased expressions of TNF-alpha, IL-1 alpha and IL-6 in chronic otitis media and a strong positive correlation between these cytokine levels and the degree of bone destruction indicate the destructive behavior of cholesteatoma or granulation tissue. Copyright (C) 2011 S. Karger AG, Basel
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页码：93 / 99
页数：7
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