The effects of Levilactobacillus brevis on the physiological parameters and gut microbiota composition of rats subjected to desynchronosis

被引:6
|
作者
Olekhnovich, Evgenii, I [1 ]
Batotsyrenova, Ekaterina G. [3 ,4 ]
Yunes, Roman A. [2 ]
Kashuro, Vadim A. [3 ,4 ]
Poluektova, Elena U. [2 ]
Veselovsky, Vladimir A. [1 ]
Ilina, Elena N. [1 ]
Danilenko, Valeriy N. [2 ]
Klimina, Ksenia M. [1 ,2 ]
机构
[1] Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, Dept Mol Biol & Genet, Moscow 119435, Russia
[2] Russian Acad Sci, Dept Genet & Biotechnol, Vavilov Inst Gen Genet, Moscow 119991, Russia
[3] St Petersburg State Pediat Med Univ, 2 Litovskaya Str, St Petersburg 194100, Russia
[4] Golikov Res Ctr Toxicol Fed Med Biol Agcy, 1 Bekhtereva Str, St Petersburg 192019, Russia
关键词
Biological rhythms; Desynchronosis; Levilactobacillus; Metagenomes; Circadian clock; Catecholamines; Gut microbiota; Antioxidant system; CIRCADIAN-RHYTHM; STRESS; LACTOBACILLUS; GLUTATHIONE; RESPONSES;
D O I
10.1186/s12934-021-01716-x
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background All living organisms have developed during evolution complex time-keeping biological clocks that allowed them to stay attuned to their environments. Circadian rhythms cycle on a near 24 h clock. These encompass a variety of changes in the body ranging from blood hormone levels to metabolism, to the gut microbiota composition and others. The gut microbiota, in return, influences the host stress response and the physiological changes associated with it, which makes it an important determinant of health. Lactobacilli are traditionally consumed for their prophylactic and therapeutic benefits against various diseases, namely, the inflammatory bowel syndrome, and even emerged recently as promising psychobiotics. However, the potential role of lactobacilli in the normalization of circadian rhythms has not been addressed. Results Two-month-old male rats were randomly divided into three groups and housed under three different light/dark cycles for three months: natural light, constant light and constant darkness. The strain Levilactobacillus brevis 47f was administered to rats at a dose of 0.5 ml per rat for one month and The rats were observed for the following two months. As a result, we identified the biomarkers associated with intake of L. brevis 47f. Changing the light regime for three months depleted the reserves of the main buffer in the cell-reduced glutathione. Intake of L. brevis 47f for 30 days restored cellular reserves of reduced glutathione and promoted redox balance. Our results indicate that the levels of urinary catecholamines correlated with light/dark cycles and were influenced by intake of L. brevis 47f. The gut microbiota of rats was also influenced by these factors. L. brevis 47f intake was associated with an increase in the relative abundance of Faecalibacterium and Roseburia and a decrease in the relative abundance of Prevotella and Bacteroides. Conclusions The results of this study show that oral administration of L. brevis 47f, for one month, to rats housed under abnormal lightning conditions (constant light or constant darkness) normalized their physiological parameters and promoted the gut microbiome's balance.
引用
收藏
页数:13
相关论文
共 50 条
  • [1] The effects of Levilactobacillus brevis on the physiological parameters and gut microbiota composition of rats subjected to desynchronosis
    Evgenii I. Olekhnovich
    Ekaterina G. Batotsyrenova
    Roman A. Yunes
    Vadim A. Kashuro
    Elena U. Poluektova
    Vladimir A. Veselovsky
    Elena N. Ilina
    Valeriy N. Danilenko
    Ksenia M. Klimina
    [J]. Microbial Cell Factories, 20
  • [2] The effects of desynchronosis on the gut microbiota composition and physiological parameters of rats
    Klimina, Ksenia M.
    Batotsyrenova, Ekaterina G.
    Yunes, Roman A.
    Gilyaeva, Elena H.
    Poluektova, Elena U.
    Kostrova, Taisia A.
    Kudryavtseva, Anna V.
    Odorskaya, Maya V.
    Kashuro, Vadim A.
    Kasianov, Artem S.
    Ivanov, Maksim B.
    Danilenko, Valery N.
    [J]. BMC MICROBIOLOGY, 2019, 19 (1)
  • [3] The effects of desynchronosis on the gut microbiota composition and physiological parameters of rats
    Ksenia M. Klimina
    Ekaterina G. Batotsyrenova
    Roman A. Yunes
    Elena H. Gilyaeva
    Elena U. Poluektova
    Taisia A. Kostrova
    Anna V. Kudryavtseva
    Maya V. Odorskaya
    Vadim A. Kashuro
    Artem S. Kasianov
    Maksim B. Ivanov
    Valery N. Danilenko
    [J]. BMC Microbiology, 19
  • [4] The protective effects of Levilactobacillus brevis FZU0713 on lipid metabolism and intestinal microbiota in hyperlipidemic rats
    Fan, Xiaoyun
    Zhang, Qing
    Guo, Weiling
    Wu, Qi
    Hu, Jinpeng
    Cheng, Wenjian
    Lue, Xucong
    Rao, Pingfan
    Ni, Li
    Chen, Youting
    Chen, Lijiao
    [J]. FOOD SCIENCE AND HUMAN WELLNESS, 2023, 12 (05) : 1646 - 1659
  • [5] The protective effects of Levilactobacillus brevis FZU0713 on lipid metabolism and intestinal microbiota in hyperlipidemic rats
    Xiaoyun Fan
    Qing Zhang
    Weiling Guo
    Qi Wu
    Jinpeng Hu
    Wenjian Cheng
    Xucong Lü
    Pingfan Rao
    Li Ni
    Youting Chen
    Lijiao Chen
    [J]. Food Science and Human Wellness, 2023, 12 (05) : 1646 - 1659
  • [6] The Effects of Formula Feeding on Physiological and Immunological Parameters in the Gut of Neonatal Rats
    Tooley, K. L.
    Howarth, G. S.
    Butler, R. N.
    Lymn, K. A.
    Penttila, I. A.
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2009, 54 (07) : 1432 - 1439
  • [7] The Effects of Formula Feeding on Physiological and Immunological Parameters in the Gut of Neonatal Rats
    K. L. Tooley
    G. S. Howarth
    R. N. Butler
    K. A. Lymn
    I. A. Penttila
    [J]. Digestive Diseases and Sciences, 2009, 54 : 1432 - 1439
  • [8] Effects of Chlorophyll on Gut Microbiota of Rats
    叶绿素对大鼠肠道菌群的影响
    [J]. Zhang, Yan (zhangyan348@163.com), 2020, Chinese Institute of Food Science and Technology (20) : 11 - 17
  • [9] Changes in gut microbiota composition with age and correlations with gut inflammation in rats
    Meng, Chen
    Feng, Siyuan
    Hao, Zikai
    Dong, Chen
    Liu, Hong
    [J]. PLOS ONE, 2022, 17 (03):
  • [10] EFFECTS OF CEREAL CONSUMPTION ON GUT MICROBIOTA COMPOSITION
    Samarin, Ivana Rumora
    Grilec, Ivona
    Samodol, Ana
    Bacic, Valentina
    Krbavcic, Ines Panjkota
    Oros, Damir
    Starcevic, Antonio
    Zucko, Jurica
    [J]. PROCEEDINGS OF THE 10TH INTERNATIONAL CONGRESS FLOUR-BREAD '19 AND 12TH CROATIAN CONGRESS OF CEREAL TECHNOLOGISTS BRASNO-KRUH '19, 2020, : 101 - 110