Design and synthesis of fluorine-substituted 3-hydroxypyridin-4-ones

被引：13
|
作者：
Ma, Yong Min [1 ]
Hider, Robert C. [1 ]
机构：
[1] Kings Coll London, Div Pharmaceut Sci, London SE1 9NH, England
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 40期
关键词：
METALATION; CHEMISTRY; FUNCTIONALIZATION; AGENT;
D O I：
10.1016/j.tetlet.2010.07.134
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The presence of fluorine in an organic molecule can dramatically alter its chemical and biological properties due to its unique characteristics. Several 2- and 5-fluorine-substituted 3-hydroxypyridin-4-ones have been synthesised with the intention of improving the pharmaceutical profile of deferiprone. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5230 / 5233
页数：4
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