Neurodevelopment of Infants with Prenatal Exposure to Polybrominated Diphenyl Ethers

被引:48
|
作者
Shy, Cherng-Gueih [1 ,2 ,3 ,4 ]
Huang, Huei-Lin [5 ]
Chang-Chien, Gou-Ping [6 ]
Chao, How-Ran [1 ]
Tsou, Tsui-Chun [7 ]
机构
[1] Natl Pingtung Univ Sci & Technol, Dept Environm Sci & Engn, Emerging Cpds Res Ctr, Neipu 912, Pingtung County, Taiwan
[2] Tajen Univ, Dept Pharm, Yanpu 907, Pingtung County, Taiwan
[3] Tajen Univ, Grad Inst Pharmaceut Technol, Yanpu 907, Pingtung County, Taiwan
[4] Pingtung Christian Hosp, Dept Radiol, Pingtung City 900, Pingtung, Taiwan
[5] Natl Cheng Kung Univ, Coll Med, Inst Behav Med, Tainan 701, Taiwan
[6] Cheng Shiu Univ, Dept Chem & Mat Engn, Kaohsiung 833, Taiwan
[7] Natl Hlth Res Inst, Div Environm Hlth & Occupat Med, Zhunan 350, Miaoli County, Taiwan
关键词
Polybrominated diphenyl ethers (PBDEs); Cord blood; Infants; Neurodevelopment; Bayley scale of infants and toddlers development; BROMINATED FLAME RETARDANTS; BREAST-MILK; MATERNAL SERUM; CORD SERUM; POPULATION; PBDES; TAIWAN;
D O I
10.1007/s00128-011-0422-9
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The study aimed to examine the impact of prenatal exposure to polybrominated diphenyl ethers (PBDEs) on infant neurodevelopment. PBDEs levels in 36 cord blood samples were analyzed with a high-resolution-gas-chromatograph/high-resolution-mass-spectrometer and infant neurodevelopment was assessed using the Bayley Scales of Infant and Toddler Development, Third Edition. The mean and median of I (11)PBDEs pound were 6.63 and 4.63 ng/g lipid, respectively. As compared to the lower PBDEs group (I (11)PBDEs pound < 4.63 ng/g lipid), the higher PBDEs group (I (11)PBDEs pound > 4.63 ng/g lipid) had a significantly higher actual odds ratio (OR = 1.13, p < 0.05) of the cognition score as well as a lower odds ratio (OR = 0.904, p < 0.01) of the adaptive behavior score, suggesting that prenatal PBDEs exposure may potentially affect infant neurodevelopment.
引用
收藏
页码:643 / 648
页数:6
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