Shape based pharmacokinetic fluorescence optical tomography

Pharmacokinetic analysis of optical fluorophore provides physiological information of the abnormalities in tissue. Compartment modeling of the fluorophore pharmacokinetics quantify the physiological changes in the tissue. We propose a shape based tomographic reconstruction of pharmacokinetic rates, concentrations and volume fractions of the fluorophore using the time varying near infra-red measurements. Radial basis function based parametric levelsets are used to represent the boundary of the spatially varying parameters of interest. A regularized Gauss-Newton filter based scheme is used reconstruct shape, pharmacokinetic rates, volume fractions and concentration parameters. Reconstruction results for tumor mimicking numerical phantom validate our proposed approach.