Development of a new delivery system consisting in 'drug-in cyclodextrin-in PLGA nanoparticles'

被引:16
|
作者
Mura, Paola [1 ]
Maestrelli, Francesca [1 ]
Cecchi, Matteo [1 ]
Bragagni, Marco [1 ]
Almeida, Antonio [2 ]
机构
[1] Univ Florence, Fac Pharm, Dept Pharmaceut Sci, I-50019 Florence, Italy
[2] Univ Lisbon, Fac Pharm, Res Inst Med & Pharm Sci iMed UL, P-1699 Lisbon, Portugal
关键词
PLGA nanoparticles; cyclodextrin complexation; oxaprozin; INFLAMMATORY-BOWEL-DISEASE; BETA-CYCLODEXTRIN; BIODEGRADABLE NANOPARTICLES; CHITOSAN MICROSPHERES; INCLUSION COMPLEXES; EFFICIENCY; OXAPROZIN; SIZE;
D O I
10.3109/02652040903515508
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded NPs, prepared by double-emulsion, were examined for dimensions, zeta-potential and entrapment efficiency. Solid-state studies demonstrated the absence of drug-polymer interactions and assessed the amorphous state of the drug-CD complex loaded into NPs. Drug release rate from NPs was strongly influenced by the presence and kind of CD used. The percentage released at 24 h varied from 16% (plain drug-loaded NPs) to 50% (drug-beta CD-loaded NPs) up to 100% (drug-methyl beta CD-loaded NPs). This result suggests the possibility of using CD complexation not only to promote, but also to regulate drug release rate from NPs, by selecting the proper type of CD or CD combination.
引用
收藏
页码:479 / 486
页数:8
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