The use of Antimicrobial Photodynamic Therapy (APDT) as a new approach to treat localized Candida infections is an emerging and promising field nowadays. The aim of this study was to verify the efficacy of photodynamic therapy using two new benzo[a]phenoxazinium photosensitizers against Candida albicans biofilms: N-(5-(3-hydroxypropylamino)-10-methyl-9H-benzo[a]phenoxazin-9-ylidene)ethanaminium chloride (FSc) and N-(5-(11-hydroxyundecylamino)-10-methyl-9H-benzo[a]phenoxazin-9-ylidene)ethanaminium chloride (FSd). The photodynamic activity of dyes against C albicans biofilms was evaluated by incubating biofilms with dyes in the range of 100-300 mu M for 3 or 18 h followed by illumination at 12 or 36 J cm(-2), using a xenon arc lamp (600 +/- 2 nm). A total photoinactivation of C albicans biofilm cells was achieved using 300 mu M of FSc with 18 h of incubation, followed by illumination at 36 J cm(-2). Contrarily, FSd had insignificant effect on biofilms inactivation by APDT. The higher uptake of FSc than FSd dye by biofilms during the dark incubation may explain the greater photodynamic effectiveness achieved with FSc. The results obtained stresses out the FSc-mediated APDT potential use to treat C albicans infections. (C) 2014 Elsevier B.V. All rights reserved.
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Sao Paulo State Univ Unesp, Sch Dent, Dept Dent Mat & Prosthodont, Araraquara, SP, Brazil
Indiana Univ Purdue Univ, Sch Dent, Dept Cariol Operat Dent & Dent Publ Hlth, Indianapolis, IN 46202 USASao Paulo State Univ Unesp, Sch Dent, Dept Dent Mat & Prosthodont, Araraquara, SP, Brazil
Panariello, Beatriz H. D.
Klein, Marlise, I
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Sao Paulo State Univ Unesp, Sch Dent, Dept Dent Mat & Prosthodont, Araraquara, SP, BrazilSao Paulo State Univ Unesp, Sch Dent, Dept Dent Mat & Prosthodont, Araraquara, SP, Brazil
Klein, Marlise, I
Alves, Fernanda
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Sao Paulo State Univ Unesp, Sch Dent, Dept Dent Mat & Prosthodont, Araraquara, SP, BrazilSao Paulo State Univ Unesp, Sch Dent, Dept Dent Mat & Prosthodont, Araraquara, SP, Brazil
Alves, Fernanda
Pavarina, Ana Claudia
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Sao Paulo State Univ Unesp, Sch Dent, Dept Dent Mat & Prosthodont, Araraquara, SP, BrazilSao Paulo State Univ Unesp, Sch Dent, Dept Dent Mat & Prosthodont, Araraquara, SP, Brazil
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Univ Vale Paraiba UNIVAP, Inst Pesquisa & Desenvolvimento IP &D, Av Shishima Hifumi 2911, BR-12244000 Sao Jose Dos Campos, BrazilUniv Vale Paraiba UNIVAP, Inst Pesquisa & Desenvolvimento IP &D, Av Shishima Hifumi 2911, BR-12244000 Sao Jose Dos Campos, Brazil
Rodrigues, Ana Beatriz Furtado
Passos, Juliene Cristina da Silva
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Univ Vale Paraiba UNIVAP, Inst Pesquisa & Desenvolvimento IP &D, Av Shishima Hifumi 2911, BR-12244000 Sao Jose Dos Campos, BrazilUniv Vale Paraiba UNIVAP, Inst Pesquisa & Desenvolvimento IP &D, Av Shishima Hifumi 2911, BR-12244000 Sao Jose Dos Campos, Brazil
Passos, Juliene Cristina da Silva
Costa, Maricilia Silva
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Univ Vale Paraiba UNIVAP, Inst Pesquisa & Desenvolvimento IP &D, Av Shishima Hifumi 2911, BR-12244000 Sao Jose Dos Campos, BrazilUniv Vale Paraiba UNIVAP, Inst Pesquisa & Desenvolvimento IP &D, Av Shishima Hifumi 2911, BR-12244000 Sao Jose Dos Campos, Brazil
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Sao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Paulo, BrazilSao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Paulo, Brazil
do Rosario Palma, Ana Luiza
de Paula-Ramos, Lucas
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Sao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Paulo, BrazilSao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Paulo, Brazil
de Paula-Ramos, Lucas
Domingues, Nadia
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Sao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Paulo, BrazilSao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Paulo, Brazil
Domingues, Nadia
Back-Brito, Graziella Nuernberg
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Sao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Paulo, BrazilSao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Paulo, Brazil
Back-Brito, Graziella Nuernberg
de Oliveira, Luciane Dias
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Sao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Paulo, BrazilSao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Paulo, Brazil
de Oliveira, Luciane Dias
Pereira, Cristiane Aparecida
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Sao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Paulo, BrazilSao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Paulo, Brazil
Pereira, Cristiane Aparecida
Cardoso Jorge, Antonio Olavo
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Sao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Paulo, BrazilSao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Paulo, Brazil