Visual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and Directions for Future Research

被引：0

作者：

Anderson, David E. ^{[1
,2
,3
]}

Holstein, Sarah A. ^{[3
,4
]}

Kedar, Sachin ^{[1
,2
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Ophthalmol & Visual Sci, Omaha, NE USA

[2] Univ Nebraska Med Ctr, Dept Neurol Sci, Omaha, NE USA

[3] Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA

[4] Univ Nebraska Med Ctr, Dept Internal Med, Div Hematol & Oncol, Omaha, NE USA

来源：

NEURO-OPHTHALMOLOGY | 2020年 / 44卷 / 03期

关键词：

Cancer; chemotherapy; electroretinography; neurotoxicity; optical coherence tomography; retina; INTACT MACAQUE EYE; MULTIPLE-SCLEROSIS; CANCER SURVIVORS; RETINAL TOXICITY; BREAST-CANCER; ELECTRORETINOGRAM; PREVALENCE; THERAPY; NEURODEGENERATION; CHEMOBRAIN;

D O I：

10.1080/01658107.2019.1702703

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Chemotherapy-related neurotoxicity (CRNT) is an emerging public health concern. Visual pathway degeneration may be a symptom of CRNT. We surveyed the current literature for evidence of visual pathway degeneration in cancer patients receiving chemotherapy. A systematic review was conducted in PubMed. Six published articles met our inclusion criteria. The studies showed reduced retinal thickness, primarily in the retinal nerve fibre layer, and impaired inner retinal function in patients receiving chemotherapy. In summary, the current literature suggests chemotherapy may induce visual pathway degeneration. Future research may benefit from improving study design, exploring mechanisms of chemotherapy-related visual pathway degeneration, and incorporating these findings into biomarker development.

引用

页码：139 / 147

页数：9

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