Hyponatremia associated with Ipilimumab-induced hypophysitis

被引：36
|
作者：
Barnard, Zachary R. [1 ,2 ]
Walcott, Brian P. [1 ,2 ]
Kahle, Kristopher T. [1 ,2 ]
Nahed, Brian V. [1 ,2 ]
Coumans, Jean Valery [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
来源：
MEDICAL ONCOLOGY | 2012年 / 29卷 / 01期
关键词：
Pituitary gland; Melanoma; Antibodies; Monoclonal; Inappropriate ADH syndrome; ANTIGEN-4; BLOCKADE; TUMOR-REGRESSION; AUTOIMMUNITY; CTLA-4;
D O I：
10.1007/s12032-010-9794-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A 75-year-old woman with a history of stage IV metastatic melanoma underwent treatment with the CTLA-4 blocking agent Ipilimumab. She presented 2 months after initiating treatment with a severe headache. Laboratories were consistent with severe hyponatremia. MRI of the brain revealed enlargement of the pituitary gland, enhancement of the infundibulum, and an enhancing, centrally necrotic foci in the anterior pituitary. Based on the clinical and radiographic findings, she was diagnosed with treatment-related syndrome of inappropriate antidiuretic hormone secretion (SIADH). Effective treatment consisted of fluid restriction, hyperosmolar therapy, and steroids.
引用
收藏
页码：374 / 377
页数：4
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