Impact of lymph node ratio in patients with stage IIIC endometrial carcinoma treated with postoperative radiotherapy

被引：5
|
作者：
Onal, Cem [1 ,3 ]
Sari, Sezin Yuce [2 ]
Yavas, Guler [3 ]
Guler, Ozan Cem [1 ]
Yigit, Ecem [2 ]
Oymak, Ezgi [4 ]
Gultekin, Melis [2 ]
Yildiz, Ferah [2 ]
机构：
[1] Baskent Univ, Fac Med, Adana Dr Turgut Noyan Res & Treatment Ctr, Dept Radiat Oncol, TR-01120 Adana, Turkey
[2] Hacettepe Univ, Fac Med, Dept Radiat Oncol, TR-06230 Ankara, Turkey
[3] Baskent Univ, Fac Med, Dept Radiat Oncol, TR-06490 Ankara, Turkey
[4] Iskenderun Gelisim Hosp, Div Radiat Oncol, TR-31200 Antakya, Turkey
来源：
FUTURE ONCOLOGY | 2021年 / 17卷 / 25期
关键词：
endometrial cancer; lymph node ratio; radiotherapy; surgery; survival; CANCER-PATIENTS; PELVIC LYMPHADENECTOMY; CHEMOTHERAPY; INVOLVEMENT; RADIATION; RESECTION; SURVIVAL; THERAPY;
D O I：
10.2217/fon-2020-1308
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: To evaluate the prognostic value of the lymph node ratio (LNR) and other clinicopathological factors in patients with stage IIIC endometrial cancer. Methods: Factors affecting overall survival (OS) and progression-free survival (PFS) were assessed in 397 patients with stage IIIC endometrial cancer treated with postoperative radiotherapy. Patients undergoing the removal of at least ten lymph nodes were included in the study. Results: The 5-year OS and PFS rates were 58% and 52%, respectively, with a median follow-up time of 35.7 months. The LNR cutoff value was 9.6%. In the multivariate analysis, advanced age (>= 60 years), grade III tumor, presence of cervical stromal invasion, higher LNR and lack of adjuvant chemotherapy were independent predictors for worse OS and PFS. Conclusion: The LNR is an independent predictor for OS and PFS in patients with stage IIIC endometrial cancer treated with postoperative radiotherapy.
引用
收藏
页码：3321 / 3330
页数：10
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