The potential of peroxisome proliferator-activated receptor γ (PPARγ) ligands in the treatment of hematological malignancies

被引：13
|
作者：
Ulivieri, C. [1 ]
Baldari, C. T. [1 ]
机构：
[1] Univ Siena, Dept Evolutionary Biol, I-53100 Siena, Italy
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 09期
关键词：
PPAR gamma ligands; cancer; immune system; cell cycle; apoptosis; TZDs; myeloid neoplasms; lymphoid neoplasms;
D O I：
10.2174/138955707781662618
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
PPAR gamma has emerged as a key regulator of cell growth and survival, whose activity is modulated by a number of synthetic and natural ligands. Here we shall review the activities of PPAR gamma ligands in the control of immune cell proliferation, differentiation and apoptosis and their potential therapeutic applications to hematological malignancies.
引用
收藏
页码：877 / 887
页数：11
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