Iodine-catalysed regioselective thiolation of flavonoids using sulfonyl hydrazides as sulfenylation reagents

被引：36
|
作者：
Zhao, Xia [1 ]
Deng, Zhijie [1 ]
Wei, Aoqi [1 ]
Li, Boyang [1 ]
Lu, Kui [2 ]
机构：
[1] Tianjin Normal Univ, Tianjin Key Lab Struct & Performance Funct Mol, Key Lab Inorgan Organ Hybrid Funct Mat Chem, Coll Chem,Minist Educ, Tianjin 300387, Peoples R China
[2] Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin 300457, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 30期
基金：
美国国家科学基金会;
关键词：
FULLY SUBSTITUTED PYRAZOLES; ANTIOXIDANT ACTIVITY; ACTIVATED ALKENES; DERIVATIVES; INHIBITION; SULFONYLHYDRAZIDES; FUNCTIONALIZATION; ARYLSULFONYLATION; SULPHENYLATION; SURROGATE;
D O I：
10.1039/c6ob01006g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Iodine-catalysed regioselective sulfenylation of flavonoid derivatives with sulfonyl hydrazides was developed. Various flavonoid thioethers were obtained in moderate to good yield. The thiolation could be conveniently directed to C-8 for flavone, flavonol, dihydroflavone, and isoflavone derivatives or to C-7 for aurone derivatives by employing the isopropyl ethers of flavonoids bearing free OH groups at the C-5 or C-4 positions.
引用
收藏
页码：7304 / 7312
页数：9
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