Antispermatogenic effect of Achillea millefolium L. in mice

被引：35
|
作者：
Montanari, T
de Carvalho, JE
Dolder, H
机构：
[1] UNICAMP, Dept Cell Biol, Inst Biol, Campinas, SP, Brazil
[2] UNICAMP, CPQBA, Campinas, SP, Brazil
来源：
CONTRACEPTION | 1998年 / 58卷 / 05期
关键词：
Achillea millefolium; medicinal plants; antispermatogenic agent; spermatogenesis; testis; male Swiss mice; yarrow;
D O I：
10.1016/S0010-7824(98)00107-3
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The effect of an ethanolic extract (200 mg/kg/day, intraperitoneally, for 20 days) and a hydroalcoholic extract (300 mg/kg/day, orally, for 30 days) of Achillea millefolium L. (yarrow) flowers on the spermatogenesis of Swiss mice was studied by evaluating morphologic characteristics with the light and electron microscopes. The alterations observed were exfoliation of immature germ cells, germ cell necrosis, acid seminiferous tubule vacuolization. Animals treated with the extracts had an increased number of metaphases in the germ epithelium that might be due to cytotoxic substances or substances stimulating cell Proliferation. (C) 1998 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：309 / 313
页数：5
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