Exercise Collapse Associated with Sickle Cell Trait (ECAST): Case Report and Literature Review

被引：21
|
作者：
Quattrone, Richard D. [1 ]
Eichner, E. Randy [2 ]
Beutler, Anthony [3 ]
Adams, W. Bruce [4 ]
O'Connor, Francis G. [5 ]
机构：
[1] Uniformed Serv Univ Hlth Sci, Primary Care Sports Med, Bethesda, MD 20814 USA
[2] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA
[3] Uniformed Serv Univ Hlth Sci, Natl Capital Consortium Sports Med, Dept Family Med, Bethesda, MD 20814 USA
[4] Naval Hlth Clin, Quantico, VA USA
[5] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA
来源：
CURRENT SPORTS MEDICINE REPORTS | 2015年 / 14卷 / 02期
关键词：
ALPHA-THALASSEMIA; HEMOGLOBIN; DEATH; GENE; RHABDOMYOLYSIS; HEMORHEOLOGY; EXPRESSION; CARRIERS; PATIENT;
D O I：
10.1249/JSR.0000000000000137
中图分类号：
G8 [体育];
学科分类号：
04 ; 0403 ;
摘要：
Sickle cell trait (SCT) has been associated with exertional collapse (ECAST) and exercise-related sudden death in athletes and military warfighters. The mechanisms underlying ECAST remain controversial in the sports medicine community. Multiple case presentations and anecdotal reports postulate the role of extraordinary exercise intensity, but other risk factors including dehydration, heat, previous exertional rhabdomyolysis, genetic cofactors, and dietary supplements have been cited as potential contributors. Others have hypothesized some of the aforementioned factors combining in a perfect storm to trigger ECAST with a resultant potentially fatal metabolic crisis. This case report provides a brief review of SCT as it pertains to exercise in warfighters and athletes, identifies known and postulated risk factors associated with ECAST, and introduces the potential mechanistic role of the double hit as a contributor to ECAST.
引用
收藏
页码：110 / 116
页数：7
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