Esterase-sensitive trithiane-based hydrogen sulfide donors

被引：8
|
作者：
Shyaka, Clovis [1 ]
Xian, Ming [2 ]
Park, Chung-Min [1 ]
机构：
[1] Gangneung Wonju Natl Univ, Dept Chem, Kangnung 25457, Gangwon, South Korea
[2] Washington State Univ, Dept Chem, Pullman, WA 99164 USA
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 47期
基金：
新加坡国家研究基金会;
关键词：
FLUORESCENT-PROBES; H2S; RELEASE; BIOCHEMISTRY; MOLECULE; INSIGHTS; BIOLOGY;
D O I：
10.1039/c9ob02273b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1,3,5-Trithiane functionalized with esterase-sensitive ester groups on the methylene linkers was developed as a class of enzymatic hydrolysis-based hydrogen sulfide (H2S) donors. The amount of H2S released from the donors was dependent on the number of ester bonds. The donors release H2S in a controllable manner in the presence of an enzyme.
引用
收藏
页码：9999 / 10003
页数：5
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