In vitro pharmacological evaluation of the dichloromethanol extract from Schinus molle L.

被引：0
|
作者：
Bello, R
Beltran, B
Moreno, L
Calatayud, S
Primo-Yufera, E
Esplugues, J
机构：
[1] Univ Valencia, Fac Med, Dept Pharmacol, Valencia 46010, Spain
[2] Univ Politecn Valencia, Dept Biotech Chem Tech Inst, Valencia 46022, Spain
[3] Fdn Juan Esplugues, Valencia 46010, Spain
来源：
PHYTOTHERAPY RESEARCH | 1998年 / 12卷 / 07期
关键词：
Schinus molle L; plant extract; smooth muscle; acetylcholine; histamine; serotonin;
D O I：
10.1002/(SICI)1099-1573(199811)12:7<523::AID-PTR337>3.0.CO;2-A
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The pharmacological activity of the dichloromethanol extract of Schinus molle L. (SM-DCM) was analysed in in vitro models. Preincubation of the isolated guinea-pig ileum or rat uterus preparations with the extract (100 mu g/mL) abolished the contractile effects of histamine and serotonin respectively. At the same dose, the extract partially reduced the contractile effects of acetylcholine on the isolated rat duodenum. A 10 mu g/mL dose showed an inhibitory effect on histamine and serotonin, but not on acetylcholine-induced contractions (NS), No significant effect was found with a 1 mu g/mL dose. (C) 1998 John Wiley & Sons, Ltd.
引用
收藏
页码：523 / 525
页数：3
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