The Decomposition of Shared Environmental Influences on Externalizing Syndromes in the Swedish Population: A Multivariate Study

被引:0
|
作者
Ohlsson, Henrik [1 ]
Kendler, Kenneth S. [2 ,3 ,4 ]
Lichtenstein, Paul [5 ]
Sundquist, Jan [1 ,6 ]
Sundquist, Kristina [1 ,6 ]
机构
[1] Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden
[2] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA
[3] Virginia Commonwealth Univ, Dept Psychiat, Richmond, VA USA
[4] Virginia Commonwealth Univ, Dept Human & Mol Genet, Richmond, VA USA
[5] Karolinska Inst, Dept Med Epidemiol & Biostat, Solna, Sweden
[6] Stanford Univ, Stanford Prevent Res Ctr, Sch Med, Stanford, CA 94305 USA
基金
瑞典研究理事会;
关键词
shared environment; close family; family; household; community; externalizing syndromes; SUBSTANCE USE DISORDERS; DRUG-ABUSE; MALE TWINS; ADOLESCENT PSYCHOPATHOLOGY; ANTISOCIAL-BEHAVIOR; NATIONAL ADOPTION; CRIMINAL BEHAVIOR; METAANALYSIS; FAMILY; RISK;
D O I
10.1017/thg.2017.31
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Using information from Swedish population registries, we attempt to decompose the shared environment (C) into four subcomponents: close family, family, household, and community. Among pairs differing in their genetic and geographical/household relationships, we examine three externalizing syndromes: drug abuse (DA), criminal behavior (CB), and alcohol use disorders (AUD). The best-fitting common pathway model suggested that total estimates for C were higher for DA (21% for males and 18% for females) than for AUD (16% and 14%) and CB (17% and 10%). Concerning syndrome-specific influences in males, close family effects were stronger for CB and AUD, while community effects were stronger for DA. The two C components in between community experiences and close family experiences (family and household) were estimated to almost entirely derive from the common latent factor. In females, among the four components of C, the community experiences were just slightly above zero, while the C components referred to as the household effect were almost zero. The total close family experiences were similar and most important across syndromes were also divided into common and specific components. For all syndromes, for both males and females, the effects of additive genetic factors were 2-4 times the size of the total effect of the shared environment. Applying standard methods to novel relationships, we expand our understanding of how the shared environment contributes to individual differences in three externalizing syndromes.
引用
收藏
页码:298 / 309
页数:12
相关论文
共 50 条
  • [1] A Swedish Population-Based Multivariate Twin Study of Externalizing Disorders
    Kenneth S. Kendler
    Sara Larsson Lönn
    Hermine H. Maes
    Paul Lichtenstein
    Jan Sundquist
    Kristina Sundquist
    [J]. Behavior Genetics, 2016, 46 : 183 - 192
  • [2] A Swedish Population-Based Multivariate Twin Study of Externalizing Disorders
    Kendler, Kenneth S.
    Lonn, Sara Larsson
    Maes, Hermine H.
    Lichtenstein, Paul
    Sundquist, Jan
    Sundquist, Kristina
    [J]. BEHAVIOR GENETICS, 2016, 46 (02) : 183 - 192
  • [3] Shared and unique genetic and environmental influences on binge eating and night eating: A Swedish twin study
    Root, Tammy L.
    Thornton, Laura M.
    Lindroos, Ann Karin
    Stunkard, Albert J.
    Lichtenstein, Paul
    Pedersen, Nancy L.
    Rasmussen, Finn
    Bulik, Cynthia M.
    [J]. EATING BEHAVIORS, 2010, 11 (02) : 92 - 98
  • [4] Are there shared genetic or environmental influences underlying externalizing behaviours, cigarette smoking and illicit drug use?
    Korhonen, Tellervo
    Latvala, Antti
    Dick, Danielle M.
    Rose, Richard R.
    Pulkkinen, Lea
    Kaprio, Jaakko
    Huizink, Anja C.
    [J]. BEHAVIOR GENETICS, 2010, 40 (06) : 800 - 800
  • [5] Genetic and environmental influences on externalizing behavior and alcohol problems in adolescence: A female twin study
    Knopik, Valerie S.
    Heath, Andrew C.
    Bucholz, Kathleen K.
    Madden, Pamela A. F.
    Waldron, Mary
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2009, 93 (03) : 313 - 321
  • [6] GENETIC AND ENVIRONMENTAL INFLUENCES ON EXTERNALIZING BEHAVIOR AND ALCOHOL PROBLEMS IN ADOLESCENCE: A FEMALE TWIN STUDY
    Knopik, V. S.
    Heath, A. C.
    Bucholz, K. K.
    Madden, P. A. F.
    Waldron, M.
    [J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2009, 33 (06) : 15A - 15A
  • [7] Genetic and environmental influences on anorexia nervosa syndromes in a population-based twin sample
    Klump, KL
    Miller, KB
    Keel, PK
    McGue, M
    Iacono, WG
    [J]. PSYCHOLOGICAL MEDICINE, 2001, 31 (04) : 737 - 740
  • [8] Genetic and environmental influences on eating behaviour - The Swedish young male twins study
    Tholin, S
    Rasmussen, F
    Tynelius, P
    Karlsson, J
    Sullivan, M
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2004, 28 : S5 - S5
  • [9] Genetic and environmental influences on eating behavior: the Swedish young male twins study
    Tholin, S
    Rasmussen, F
    Tynelius, P
    Karlsson, J
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2005, 81 (03): : 564 - 569
  • [10] Genetic and environmental influences on adult attention deficit hyperactivity disorder symptoms: a large Swedish population-based study of twins
    Larsson, H.
    Asherson, P.
    Chang, Z.
    Ljung, T.
    Friedrichs, B.
    Larsson, J. -O.
    Lichtenstein, P.
    [J]. PSYCHOLOGICAL MEDICINE, 2013, 43 (01) : 197 - 207