A Review Exploring Therapeutic Worth of 1,3,4-Oxadiazole Tailored Compounds

被引:75
|
作者
Verma, Garima [1 ]
Khan, Mohemmed F. [1 ]
Akhtar, Wasim [1 ]
Alam, Mohammad Mumtaz [1 ]
Akhter, Mymoona [1 ]
Shaquiquzzaman, Mohammad [1 ]
机构
[1] Jamia Hamdard, Dept Pharmaceut Chem, Sch Pharmaceut Educ & Res, New Delhi 11062, India
关键词
1,3,4-Oxadiazole; therapeutic worth; anticancer; antimicrobial; antioxidant; isoforms; VITRO ANTIPROLIFERATIVE ACTIVITY; BETA-GLUCURONIDASE INHIBITORS; MICROWAVE-ASSISTED SYNTHESIS; BIOLOGICAL EVALUATION; IN-VITRO; MOLECULAR DOCKING; PHARMACOLOGICAL EVALUATION; ANTIOXIDANT ACTIVITY; ANTITUMOR-ACTIVITY; ANTIMICROBIAL ACTIVITY;
D O I
10.2174/1389557518666181015152433
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
1,3,4-Oxadiazole, a five-membered aromatic ring can he seen in a number of synthetic molecules. The peculiar structural feature of 1,3,4-oxadiazole ring with pyridine type of nitrogen atom is beneficial for 1,3,4-oxadiazole derivatives to have effective binding with different enzymes and receptors in biological systems through numerous weak interactions, thereby eliciting an array of bioactivities. Research in the area of development of 1,3,4-oxadiazole-based derivatives has become an interesting topic for the scientists. A number of 1,3,4-oxadiazole based compounds with high therapeutic potency are being extensively used for the treatment of different ailments, contributing to enormous development value. This work provides a systematic and comprehensive review highlighting current developments of 1,3,4-oxadiazole based compounds in the entire range of medicinal chemistry such as anticancer, antifungal, antibacterial, antitubercular, anti-inflammatory, antineuropathic, antihypertensive, antihistaminic, antiparasitic, antiobesity, antiviral, and other medicinal agents. It is believed that this review will he of great help for new thoughts in the pursuit for rational designs for the development of more active and less toxic 1,3,4-oxadiazole based medicinal agents.
引用
收藏
页码:477 / 509
页数:33
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