Inhaled corticosteroid use for asthma is linked to adrenal suppression

被引:1
|
作者
Lasky-Su, Jessica [1 ,2 ]
机构
[1] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA
[2] Harvard Med Sch, Boston, MA 02115 USA
关键词
D O I
10.1038/s41591-022-01732-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The largest metabolomic study of asthma thus far, comprising >14,000 people from four independent cohorts, has found that inhaled corticosteroid (ICS) treatment is associated with adrenal suppression, even at low doses. Thus, ICS dosage should be optimized to minimize adrenal suppression while maintaining its established benefits in asthma management.
引用
下载
收藏
页码:645 / 646
页数:2
相关论文
共 50 条
  • [2] Omalizumab and allergen immunotherapy in a patient with asthma and inhaled corticosteroid-induced adrenal suppression
    Forbush, Jason T.
    Banks, Taylor A.
    ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2016, 117 (03) : 335 - 337
  • [3] Adrenal suppression, asthma and inhaled steroids
    Isaacs, David
    JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 2017, 53 (10) : 1027 - 1028
  • [4] Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma
    Kachroo, Priyadarshini
    Stewart, Isobel D.
    Kelly, Rachel S.
    Stav, Meryl
    Mendez, Kevin
    Dahlin, Amber
    Soeteman, Djora I.
    Chu, Su H.
    Huang, Mengna
    Cote, Margaret
    Knilhtila, Hanna M.
    Lee-Sarwar, Kathleen
    McGeachie, Michael
    Wang, Alberta
    Wu, Ann Chen
    Virkud, Yamini
    Zhang, Pei
    Wareham, Nicholas J.
    Karlson, Elizabeth W.
    Wheelock, Craig E.
    Clish, Clary
    Weiss, Scott T.
    Langenberg, Claudia
    Lasky-Su, Jessica A.
    NATURE MEDICINE, 2022, 28 (04) : 814 - 822
  • [5] Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma
    Priyadarshini Kachroo
    Isobel D. Stewart
    Rachel S. Kelly
    Meryl Stav
    Kevin Mendez
    Amber Dahlin
    Djøra I. Soeteman
    Su H. Chu
    Mengna Huang
    Margaret Cote
    Hanna M. Knihtilä
    Kathleen Lee-Sarwar
    Michael McGeachie
    Alberta Wang
    Ann Chen Wu
    Yamini Virkud
    Pei Zhang
    Nicholas J. Wareham
    Elizabeth W. Karlson
    Craig E. Wheelock
    Clary Clish
    Scott T. Weiss
    Claudia Langenberg
    Jessica A. Lasky-Su
    Nature Medicine, 2022, 28 : 814 - 822
  • [6] Inhaled Corticosteroid-Induced Adrenal Suppression in Patients With Asthma Detected by Metabolomic Profiling
    Chiarella, Sergio E.
    Bancos, Irina
    Ortega, Victor E.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2022, 10 (10): : 2774 - 2775
  • [7] Prevalence of Hypothalamic-Pituitary-Adrenal Axis Suppression in Children Treated for Asthma with Inhaled Corticosteroid
    Smith, R. W.
    Downey, K. K.
    Gordon, M.
    Hudak, A.
    Meeder, R.
    Barker, S.
    Chroinin, M. Ni
    Smith, W. G.
    IRISH JOURNAL OF MEDICAL SCIENCE, 2011, 180 : S451 - S451
  • [8] Prevalence of hypothalamic-pituitary-adrenal axis suppression in children treated for asthma with inhaled corticosteroid
    Smith, Ryan W.
    Downey, Kim
    Gordon, Michelle
    Hudak, Alan
    Meeder, Rob
    Barker, Sarah
    Smith, W. Gary
    PAEDIATRICS & CHILD HEALTH, 2012, 17 (05) : E34 - E39
  • [9] Effect of long term inhaled corticosteroid therapy on adrenal suppression, growth and bone health in children with asthma
    Anuradha KWDA
    Prematilake GLDC
    Batuwita BAUI
    Kannangoda KASR
    Hewagamage US
    Wijeratne S
    Lankatilake Kantha
    de Silva KSH
    BMC Pediatrics, 19
  • [10] Effect of long term inhaled corticosteroid therapy on adrenal suppression, growth and bone health in children with asthma
    Anuradha, K. W. D. A.
    Prematilake, G. L. D. C.
    Batuwita, B. A. U., I
    Kannangoda, K. A. S. R.
    Hewagamage, U. S.
    Wijeratne, S.
    Kantha, Lankatilake
    de Silva, K. S. H.
    BMC PEDIATRICS, 2019, 19 (01)