Micafungin Concentrations in the Plasma and Burn Eschar of Severely Burned Patients

被引：16

作者：

Sasaki, Junichi ^{[1
]}

Yamanouchi, Satoshi ^{[2
]}

Kudo, Daisuke ^{[2
]}

Endo, Tomoyuki ^{[2
]}

Nomura, Ryosuke ^{[2
]}

Takuma, Kiyotsugu ^{[1
]}

Kushimoto, Shigeki ^{[2
]}

Shinozawa, Yotaro

Kishino, Satoshi ^{[3
]}

Hori, Shingo ^{[1
]}

Aikawa, Naoki ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Emergency & Crit Care Med, Tokyo, Japan

[2] Tohoku Univ, Grad Sch Med, Div Emergency Med, Sendai, Miyagi 980, Japan

[3] Meiji Pharmaceut Univ, Dept Medicat Use Anal & Clin Res, Tokyo, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 02期

关键词：

FUNGAL-INFECTIONS; PHARMACOKINETICS; DISPOSITION; LIVER; CARE;

D O I：

10.1128/AAC.05381-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Micafungin concentrations in plasma and burn eschar after daily intravenous infusion (1 h) of micafungin (200 to 300 mg) were investigated for six patients with severe burns. Micafungin treatment was initiated more than 72 h after the burn injuries. The peak and trough levels in the plasma after the initial administration and repeated administrations for more than 4 days were comparable with or slightly lower than the reported values for healthy volunteers. Micafungin concentrations in the plasma and burn eschar were between 3.6 and >1,000 times higher than the reported MIC(90)s of micafungin against clinically important Candida and Aspergillus species.

引用

页码：1113 / 1115

页数：3

共 50 条

[1] Penetration of micafungin into the burn eschar in patients with severe burns
Sasaki, Junichi
Yamanouchi, Satoshi
Sato, Yukio
Abe, Shinya
Shinozawa, Yotaro
Kishino, Satoshi
Aikawa, Naoki
Hori, Shingo
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2014, 39 (02) : 93 - 97
[2] Penetration of micafungin into the burn eschar in patients with severe burns
Junichi Sasaki
Satoshi Yamanouchi
Yukio Sato
Shinya Abe
Yotaro Shinozawa
Satoshi Kishino
Naoki Aikawa
Shingo Hori
European Journal of Drug Metabolism and Pharmacokinetics, 2014, 39 : 93 - 97
[3] PHARMACOKINETICS OF MICAFUNGIN IN PLASMA AND BURN ESCHARES IN CRITICALLY ILL BURNED PATIENTS
Jose Asensio, Maria
Sanchez, Manuel
Galvan, Beatriz
Herrero, Eva
Cachafeiro, Lucia
Agrifolio, Alexander
Luque, Sonia
Garcia-de-Lorenzo, Abelardo
CRITICAL CARE MEDICINE, 2014, 42 (12)
[4] Micafungin concentrations 100 mg daily in plasma and burn eschars in patients with severe burn injuries
A Agrifoglio
MJ Asensio
M Sánchez
B Galván
E Herrero
L Cachafeiro
E Perales
S Luque
A García de Lorenzo
Critical Care, 19 (Suppl 1):
[5] Oxandrolone Coadministration Does Not Alter Plasma Propranolol Concentrations in Severely Burned Pediatric Patients
Guillory, Ashley N.
Herndon, David N.
Silva, Michael B., III
Andersen, Clark R.
Suman, Oscar E.
Finnerty, Celeste C.
JOURNAL OF BURN CARE & RESEARCH, 2017, 38 (04): : 243 - 250
[6] PROTEOLYTIC ACTIVITY IN PLASMA IN SEVERELY BURNED PATIENTS
RUUD, TE
KIERULF, P
GODAL, HC
AUNE, S
AASEN, AO
INTERNATIONAL JOURNAL OF MICROCIRCULATION-CLINICAL AND EXPERIMENTAL, 1983, 2 (04): : 356 - 356
[7] CONCENTRATIONS OF MICAFUNGIN 100 MG DAILY IN PLASMA AND BURN ESCHARES IN CRITICALLY ILL PATIENTS waif SEVERE BURN INJURIES
Asensio, M. J.
Sanchez Sanchez, M.
Galvan Guijo, B.
Herrero de Lucas, E.
Cachafeiro Fucinos, L.
Agrifoglio Rotaeche, A.
Perales Ferrera, E.
Luque, S.
Garcia de Lorenzo y Mateos, A.
INTENSIVE CARE MEDICINE, 2014, 40 : S130 - S130
[8] PLASMA-CONCENTRATIONS OF VASOACTIVE INTESTINAL POLYPEPTIDE IN SEVERELY BURNED PATIENTS - INFLUENCE OF ENTERAL NUTRITION
VAUBOURDOLLE, M
SALVUCCI, M
CYNOBER, L
LIORET, N
SAIZY, R
GIBOUDEAU, J
CLINICAL NUTRITION, 1986, 5 (04) : 217 - 220
[9] Effect of primary admission to burn centers on the outcomes of severely burned patients
Ehrl, Denis
Heidekrueger, Paul I.
Ninkovic, Milomir
Broer, P. Niclas
BURNS, 2018, 44 (03) : 524 - 530
[10] ENTEROCOCCAL BURN SEPSIS - A HIGHLY LETHAL COMPLICATION IN SEVERELY BURNED PATIENTS
JONES, WG
BARIE, PS
YURT, RW
GOODWIN, CW
ARCHIVES OF SURGERY, 1986, 121 (06) : 649 - 653

← 1 2 3 4 5 →