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- [1] Discovery of L-791,943:: A potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (11) : 1457 - 1461Guay, D论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaHamel, P论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaBlouin, M论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaBrideau, C论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaChan, CC论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaChauret, N论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaDucharme, Y论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaHuang, Z论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaGirard, M论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaJones, TR论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaLaliberté, F论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaMasson, P论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaMcAuliffe, M论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaPiechuta, H论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaSilva, J论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaYoung, RN论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, CanadaGirard, Y论文数: 0 引用数: 0 h-index: 0机构: Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9R 4P8, Canada
- [2] 2,3-disubstituted pyridine derivatives as non-emetic phosphodiesterase type 4 inhibitors.[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U950 - U951Nigo, T论文数: 0 引用数: 0 h-index: 0机构: Dainippon Pharmaceut Co Ltd, Discovery Chem Grp 1, Suita, Osaka 5650053, JapanNakamura, S论文数: 0 引用数: 0 h-index: 0机构: Dainippon Pharmaceut Co Ltd, Discovery Chem Grp 1, Suita, Osaka 5650053, JapanYoshioka, S论文数: 0 引用数: 0 h-index: 0机构: Dainippon Pharmaceut Co Ltd, Discovery Chem Grp 1, Suita, Osaka 5650053, JapanTeranishi, Y论文数: 0 引用数: 0 h-index: 0机构: Dainippon Pharmaceut Co Ltd, Discovery Chem Grp 1, Suita, Osaka 5650053, JapanItch, MN论文数: 0 引用数: 0 h-index: 0机构: Dainippon Pharmaceut Co Ltd, Discovery Chem Grp 1, Suita, Osaka 5650053, JapanKawasaki, M论文数: 0 引用数: 0 h-index: 0机构: Dainippon Pharmaceut Co Ltd, Discovery Chem Grp 1, Suita, Osaka 5650053, Japan
- [3] ASP3258, an orally active potent phosphodiesterase 4 inhibitor with low emetic activity[J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2011, 11 (06) : 732 - 739Kobayashi, Miki论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Drug Discovery Res, Pharmacol Res Labs, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Drug Discovery Res, Pharmacol Res Labs, Tsukuba, Ibaraki 3058585, JapanKubo, Satoshi论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Drug Discovery Res, Pharmacol Res Labs, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Drug Discovery Res, Pharmacol Res Labs, Tsukuba, Ibaraki 3058585, JapanIwata, Masahiro论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Intellectual Property, Chuo Ku, Tokyo 1038411, Japan Astellas Pharma Inc, Drug Discovery Res, Pharmacol Res Labs, Tsukuba, Ibaraki 3058585, JapanOhtsu, Yoshiaki论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Drug Metab Res Labs, Yodogawa Ku, Osaka 5328514, Japan Astellas Pharma Inc, Drug Discovery Res, Pharmacol Res Labs, Tsukuba, Ibaraki 3058585, JapanTakahashi, Koichiro论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Drug Discovery Res, Pharmacol Res Labs, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Drug Discovery Res, Pharmacol Res Labs, Tsukuba, Ibaraki 3058585, JapanShimizu, Yasuaki论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Drug Discovery Res, Pharmacol Res Labs, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Drug Discovery Res, Pharmacol Res Labs, Tsukuba, Ibaraki 3058585, Japan
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