Functions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma

被引：44

作者：

Wu, Qi ^{[1
]}

Tian, Ying ^{[1
]}

Zhang, Jingqiu ^{[2
]}

Zhang, Hongpeng ^{[1
]}

Gu, Fengming ^{[1
]}

Lu, Yongdie ^{[1
]}

Zou, Shengnan ^{[1
]}

Chen, Yuji ^{[1
]}

Sun, Pengxiang ^{[1
]}

Xu, Mengyue ^{[1
]}

Sun, Xiaoming ^{[1
]}

Xia, Chao ^{[3
]}

Chi, Hao ^{[1
]}

Zhu, A. Ying ^{[1
]}

Tang, Dong ^{[2
]}

Wang, Daorong ^{[2
]}

机构：

[1] Yangzhou Univ, Med Coll, Yangzhou, Jiangsu, Peoples R China

[2] Yangzhou Univ, Inst Gen Surg, Northern Jiangsu Prov Hosp, Dept Gen Surg,Clin Med Coll, Yangzhou, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Nanjing, Jiangsu, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 60期

关键词：

transforming growth factor beta (TGF-beta); interleukin 6(IL-6); galectin-1; stromal cell-derived factor-1(SDF-1); hepatocyte growth factor (HGF); EPITHELIAL-MESENCHYMAL TRANSITION; HEPATOCYTE GROWTH-FACTOR; PHASE-III TRIAL; TGF-BETA; CANCER CELLS; ADENOCARCINOMA CELLS; PREMETASTATIC NICHE; POTENT INHIBITOR; STROMAL BIOLOGY; DOWN-REGULATION;

D O I：

10.18632/oncotarget.21970

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer with poor prognosis because it is highly resistant to traditional chemotherapy and radiotherapy and it has a low rate of surgical resection eligibility. Pancreatic stellate cells (PSC) have become a research hotspot in recent years, and play a vital role in PDAC microenvironment by secreting soluble factors such as transforming growth factor beta, interleukin-6, stromal cell-derived factor-1, hepatocyte growth factor and galectin-1. These PSC-derived cytokines and proteins contribute to PSC activation, participating in PDAC cell proliferation, migration, fibrosis, angiogenesis, immunosuppression, epithelial-mesenchymal transition, and chemoradiation resistance, leading to malignant outcome. Consequently, targeting these cytokines and proteins or their downstream signaling pathways is promising for treating PDAC.

引用

页码：102721 / 102738

页数：18

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