Autologous haemopoietic stem cell transplantation for autoimmune diseases

被引：12
|
作者：
Zeher, Margit [1 ]
Papp, Gabor [1 ]
Szodoray, Peter [2 ]
机构：
[1] Univ Debrecen, Div Clin Immunol, Dept Med 3, Med & Hlth Sci Ctr, H-4032 Debrecen, Hungary
[2] Univ Oslo, Rikshosp, Inst Immunol, N-0027 Oslo, Norway
来源：
EXPERT OPINION ON BIOLOGICAL THERAPY | 2011年 / 11卷 / 09期
关键词：
autoimmune diseases; autologous hemopoietic stem cell transplantation; clinical response; immunological background; BONE-MARROW-TRANSPLANTATION; SYSTEMIC-LUPUS-ERYTHEMATOSUS; TERM-FOLLOW-UP; JUVENILE IDIOPATHIC ARTHRITIS; SEVERE RHEUMATOID-ARTHRITIS; TYPE-1; DIABETES-MELLITUS; AUTOREACTIVE T-CELLS; MULTIPLE-SCLEROSIS; IMMUNE HOMEOSTASIS; BEHCETS-DISEASE;
D O I：
10.1517/14712598.2011.580272
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Areas covered: In this review, the authors describe the compound cellular regulatory effects of autologous hemopoietic stem cell transplantation (ASCT) and also clinical observations, related to the therapy in a variety of organ-specific and systemic autoimmune diseases. Expert opinion: ASCT has a broad effect on the re-populated immune system, complex regulatory potentials and long term beneficial effect via down-regulating immune-reactivity, yet its widespread use in autoimmune diseases is limited, mostly due to the serious side-effects of the conditioning treatments. However, in certain autoimmune diseases with severe debilitating, or even life-threatening course, including systemic lupus erythematosus, systemic sclerosis or multiple sclerosis, ASCT can be a reasonable choice when conventional therapy has failed.
引用
收藏
页码：1193 / 1201
页数：9
相关论文
共 50 条
  • [1] Haemopoietic stem cell transplantation for autoimmune diseases
    Snowden, JA
    Brooks, PM
    Biggs, JC
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 1997, 99 (01) : 9 - 22
  • [2] Haemopoietic stem cell transplantation in autoimmune diseases: a European perspective
    Hough, RE
    Snowden, JA
    Wulffraat, NM
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2005, 128 (04) : 432 - 459
  • [3] Autologous stem cell transplantation in autoimmune diseases
    Passweg, Jakob
    Tyndall, Alan
    [J]. SEMINARS IN HEMATOLOGY, 2007, 44 (04) : 278 - 285
  • [4] The role of autologous haemopoietic stem cell transplantation in the treatment of autoimmune disorders
    Rebeiro, P.
    Moore, J.
    [J]. INTERNAL MEDICINE JOURNAL, 2016, 46 (01) : 17 - 28
  • [5] Autologous haemopoietic stem cell transplantation
    Collins, RH
    [J]. LANCET, 1997, 349 (9055): : 881 - 881
  • [6] Autologous hematopoietic stem cell transplantation in autoimmune diseases
    Annaloro, Claudio
    Onida, Francesco
    Deliliers, Giorgio Lambertenghi
    [J]. EXPERT REVIEW OF HEMATOLOGY, 2009, 2 (06) : 699 - 715
  • [7] Autologous hematopoietic stem cell transplantation for autoimmune diseases
    Gratwohl, A
    Passweg, J
    Bocelli-Tyndall, C
    Fassas, A
    van Laar, JM
    Farge, D
    Andolina, M
    Arnold, R
    Carreras, E
    Finke, J
    Kötter, I
    Kozak, T
    Lisukov, I
    Löwenberg, B
    Marmont, A
    Moore, J
    Saccardi, R
    Snowden, JA
    van den Hoogen, F
    Wulffraat, NM
    Zhao, XW
    Tyndall, A
    [J]. BONE MARROW TRANSPLANTATION, 2005, 35 (09) : 869 - 879
  • [8] Autologous hematopoietic stem cell transplantation for autoimmune diseases
    A Gratwohl
    J Passweg
    C Bocelli-Tyndall
    A Fassas
    J M van Laar
    D Farge
    M Andolina
    R Arnold
    E Carreras
    J Finke
    I Kötter
    T Kozak
    I Lisukov
    B Löwenberg
    A Marmont
    J Moore
    R Saccardi
    J A Snowden
    F van den Hoogen
    N M Wulffraat
    X W Zhao
    A Tyndall
    [J]. Bone Marrow Transplantation, 2005, 35 : 869 - 879
  • [9] Autologous stem cell transplantation for treatment of autoimmune diseases
    van Bekkum, DW
    [J]. STEM CELLS, 1999, 17 (03) : 172 - 178
  • [10] Autologous blood stem cell transplantation for autoimmune diseases
    Snowden, JA
    Biggs, JC
    Brooks, PM
    [J]. LANCET, 1996, 348 (9035): : 1112 - 1113
12345