Letrozole Potentiometric PVC membrane and Nano-Composite Carbon Paste Electrodes

Two kinds of potentiometric electrodes, based on PVC membrane and nano-composite carbon paste electrodes have been introduced. The ion-pair, which was synthesized by the interaction of Letrozole and tetraphenyl borate, was used as a sensing element in both kinds of the electrode. The electrodes respond according to the ion-exchange mechanism. The best PVC membrane sensor response was obtained by a membrane composition of 30% PVC, 65% NB, and 5% ion-pair. Carbon paste electrode was then designed to have an electrode with the better mechanical resistance. The best electrode was composed of 20% ion-pair, 20% paraffin oil, 5% MWCNTs and 55% graphite powder. The proposed method was successfully applied in determination of Letrozole in some pharmaceutical formulations.