Measurement of the traction force of biological cells by digital holography

被引：44
|
作者：
Yu, Xiao [1 ]
Cross, Michael [2 ]
Liu, Changgeng [1 ]
Clark, David C. [1 ]
Haynie, Donald T. [2 ]
Kim, Myung K. [1 ]
机构：
[1] Univ S Florida, Dept Phys, Digital Holog & Microscopy Lab, Tampa, FL 33620 USA
[2] Univ S Florida, Dept Phys, Nanomed & Nanobiotechnol Lab, Tampa, FL 33620 USA
来源：
BIOMEDICAL OPTICS EXPRESS | 2012年 / 3卷 / 01期
基金：
美国国家科学基金会;
关键词：
LOCOMOTION; SUBSTRATE; MODULI;
D O I：
10.1364/BOE.3.000153
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The traction force produced by biological cells has been visualized as distortions in flexible substrata. We have utilized quantitative phase microscopy by digital holography (DH-QPM) to study the wrinkling of a silicone rubber film by motile fibroblasts. Surface deformation and the cellular traction force have been measured from phase profiles in a direct and straightforward manner. DH-QPM is shown to provide highly efficient and versatile means for quantitatively analyzing cellular motility. (C) 2011 Optical Society of America
引用
收藏
页码：153 / 159
页数：7
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