The Role and Application of Exosomes in Gastric and Colorectal Cancer

被引：5
|
作者：
Li, Qirong [1 ,2 ]
Wang, Dongxu [2 ]
Ding, Dayong [1 ]
Feng, Ye [1 ]
Hou, Ruizhi [1 ]
Liu, Dianfeng [2 ]
Lin, Chao [3 ]
Gao, Yongjian [1 ]
机构：
[1] Jilin Univ, Dept Gastrointestinal Colorectal & Anal Surg, China Japan Union Hosp, Changchun, Peoples R China
[2] Jilin Univ, Coll Anim Sci, Lab Anim Ctr, Changchun, Peoples R China
[3] Jilin Business & Technol Coll, Sch Grain Sci & Technol, Changchun, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2022年 / 12卷
关键词：
gastric cancer; colorectal cancer; ncRNA; exosomes; cancer therapy; REVERSE CHEMORESISTANCE; PROGRESSION; CELLS; NANOPARTICLES; BIOMARKERS; CISPLATIN; PROMOTE; SERVE;
D O I：
10.3389/fphar.2021.825475
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Gastric cancer and colorectal cancer are malignant tumors found in the human gastrointestinal tract. Bidirectional communication between tumor cells and their microenvironment can be realized through the transmission of exosomes-small, cell-derived vesicles containing complex RNA and proteins. Exosomes play an important role in the proliferation, metastasis, immune response, and drug resistance of cancer cells. In this review, we focus on the role and application of exosomes in gastric and colorectal cancer. We also summarize the role of exosomes secreted by different types of cells in tumor development and as drug carriers in cancer treatment.
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页数：6
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