Comparison of Moisturizing Creams for the Prevention of Atopic Dermatitis Relapse: A Randomized Double-blind Controlled Multicentre Clinical Trial

被引：59

作者：

Akerstrom, Ulf ^{[1
]}

Reitamo, Sakari ^{[2
]}

Langeland, Tor ^{[3
]}

Berg, Mats ^{[4
]}

Rustad, Lisbeth ^{[5
]}

Korhonen, Laura ^{[6
,7
]}

Loden, Marie ^{[8
]}

Wiren, Karin ^{[1
]}

Grande, Mats ^{[1
]}

Skare, Petra ^{[1
]}

Svensson, Ake ^{[9
]}

机构：

[1] ACO Hud Nord AB, Dept Innovat, SE-19426 Upplands Vasby, Sweden

[2] Univ Helsinki, Skin & Allergy Hosp, Helsinki, Finland

[3] Hudlege Tor Langelands Kontor, Oslo, Norway

[4] Malar Hosp, Dept Dermatol, Eskilstuna, Sweden

[5] Haukeland Hosp, Dept Dermatol, N-5021 Bergen, Norway

[6] Tampere Univ Hosp, Allergy Ctr, Tampere, Finland

[7] Tampere Univ Hosp, Dept Dermatol, Tampere, Finland

[8] Eviderm Inst AB, Solna, Sweden

[9] Skane Univ Hosp, Dept Dermatol, Malmo, Sweden

来源：

ACTA DERMATO-VENEREOLOGICA | 2015年 / 95卷 / 05期

关键词：

atopic dermatitis; atopic eczema; emollients; moisturizer; prevention; urea; SKIN BARRIER FUNCTION; ECZEMATOUS SKIN; DRY SKIN; CHILDREN; UREA; EMOLLIENTS; SUSCEPTIBILITY;

D O I：

10.2340/00015555-2051

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Atopic dermatitis (AD) affects adults and children and has a negative impact on quality of life. The present multicentre randomized double-blind controlled trial showed a barrier-improving cream (5% urea) to be superior to a reference cream in preventing eczema relapse in patients with AD (hazard ratio 0.634, p = 0.011). The risk of eczema relapse was reduced by 37% (95% confidence interval (95% CI) 10-55%). Median time to relapse in the test cream group and in the reference cream group was 22 days and 15 days, respectively (p = 0.013). At 6 months 26% of the patients in the test cream group were still eczema free, compared with 10% in the reference cream group. Thus, the barrier-improving cream significantly prolonged the eczema-free time compared with the reference cream and decreased the risk of eczema relapse. The test cream was well tolerated in patients with AD.

引用

页码：587 / 592

页数：6

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