SARS-CoV-2 Variants Are Selecting for Spike Protein Mutations That Increase Protein Stability

被引：10

作者：

Shorthouse, David ^{[1
]}

Hall, Benjamin A. ^{[1
]}

机构：

[1] UCL, Dept Med Phys & Biomed Engn, London WC1E 6BT, England

来源：

JOURNAL OF CHEMICAL INFORMATION AND MODELING | 2021年 / 61卷 / 09期

基金：

英国医学研究理事会;

关键词：

All Open Access; Green;

D O I：

10.1021/acs.jcim.1c00990

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The emergence of variants of SARS-CoV-2 with mutations in their spike protein are a major cause for concern for the efficacy of vaccines and control of the pandemic. We show that mutations in the spike protein of SARS-CoV-2 are selecting for amino acid changes that result in a more thermodynamically stable protein than expected from background. We suggest that the computationally efficient analysis of mutational stability may aid in early screening of variants.

引用

页码：4152 / 4155

页数：4

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