Titanium-based metal-organic frameworks as potential chloroquine drug carriers

被引：7
|
作者：
Zhang, Li [1 ]
Tian, Jie [1 ]
Cao, Fang [1 ]
Zhu, Zi-Yi [2 ]
Hong, Fuyuan [1 ]
Wu, Jiabin [1 ]
Wang, Fei [2 ]
机构：
[1] Fujian Med Univ, Fujian Prov Hosp, Prov Clin Med Coll, Fuzhou, Fujian, Peoples R China
[2] Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2021年 / 133卷
基金：
中国国家自然科学基金;
关键词：
Metal-organic frameworks chloroquine; Ti-MOFs; Porous carriers; Drug delivery; Drug release;
D O I：
10.1016/j.inoche.2021.108870
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In this work, we report the syntheses and characterizations of two titanium-based metal-organic frameworks (Ti-MOFs), MIL-125 and MIL-125-NH2 as potential drug carriers for chloroquine (CQ). Both materials exhibited high loading capability for CQ owing to their large surface area. The sustainable CQ release could reach ca. 70% after 13 days in phosphate buffer solution. The experimental results suggested that Ti-MOFs could be a valuable CQ carriers to realize the slow release.
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页数：3
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