Hesperine, a new imidazole alkaloid and a-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia

被引：5

作者：

Prebble, Dale W. ^{[1
,2
]}

Voser, Tanja M. ^{[1
]}

Er, Safak ^{[3
,4
]}

Hlushchuk, Irena ^{[3
]}

Domanskyi, Andrii ^{[4
]}

Airavaara, Mikko ^{[3
,5
]}

Ekins, Merrick G. ^{[2
,6
]}

Mellick, George D. ^{[1
,2
]}

Carroll, Anthony R. ^{[1
,2
]}

机构：

[1] Griffith Univ, Sch Environm & Sci, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia

[2] Griffith Univ, Griffith Inst Drug Discovery, Brisbane Innovat Pk,Don Young Rd, Nathan, Qld 4111, Australia

[3] Univ Helsinki, Fac Pharm, Helsinki 00014, Finland

[4] Univ Helsinki, Inst Biotechnol, HiLIFE, Helsinki 00014, Finland

[5] Univ Helsinki, Neurosci Ctr, HiLIFE, Helsinki 00014, Finland

[6] Queensland Museum, South Brisbane Bc, Qld 4101, Australia

来源：

RESULTS IN CHEMISTRY | 2022年 / 4卷

基金：

芬兰科学院;

关键词：

Amyloid; alpha-Synuclein; Clathria (Thalysias) cf. hesperia; Alkaloids; ALPHA-SYNUCLEIN; ALZHEIMERS-DISEASE; AGGREGATION; MECHANISM;

D O I：

10.1016/j.rechem.2022.100302

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Clathria (Thalysias) cf. hesperia was identified with alpha-synuclein binding activity. The bioassay-guided purification of this extract resulted in the isolation of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2) as the alpha-syn binder along with one new compound, hesperine (1), and five known compounds, indole-3-carboxaldehyde (3), (Z)-2'-demethylaplysinopsin (4), 2-amino-4'-hydroxyacetophenone (5), 4-hydroxybenzoic acid (6) and 4-hydroxybenzaldehyde (7). Herein, we report the structure elucidation of hesperine (1) and alpha-syn binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2)

引用

页数：4