2,5-Diketopiperazines from the Marine-Derived Fungus Aspergillus fumigatus YK-7

被引：42

作者：

Wang, Yu ^{[1
,2
]}

Li, Zhan-Lin ^{[1
,2
]}

Bai, Jiao ^{[1
,2
]}

Zhang, Li-Min ^{[1
,2
]}

Wu, Xin ^{[3
]}

Zhang, Lin ^{[1
,2
]}

Pei, Yue-Hu ^{[1
,2
]}

Jing, Yong-Kui ^{[4
]}

Hua, Hui-Ming ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China

[4] Mt Sinai Sch Med, New York, NY 10029 USA

来源：

CHEMISTRY & BIODIVERSITY | 2012年 / 9卷 / 02期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

Piperazine-2; 5-diones; Aspergillus fumigatus; Marine natural products; Fungi; Antiproliferative activity; CELL CYCLE INHIBITORS; FUMAGILLIN; VERRUCULOGEN; GLIOTOXIN; TNP-470;

D O I：

10.1002/cbdv.201100061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five new diketopiperazines, prenylcyclotryprostatin B (1), 20-hydroxycyclotryprostatin B (2), 9-hydroxyfumitremorgin C (3), 6-hydroxytryprostatin B (4), and spirogliotoxin (5), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with nine known compounds, 614. Their structures were elucidated by spectroscopic methods, and their antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were assessed in vitro. Compounds 10, 12, and 13 exhibited significant cell growth-inhibitory activities against U937 cell line, with the IC50 values of 1.8, 0.2, and 0.5 mu M, respectively.

引用

页码：385 / 393

页数：9

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