An Iodine-Mediated Hofmann-Loffler-Freytag Reaction of Sulfoximines Leading to Dihydroisothiazole Oxides

被引：41

作者：

Zhang, Duo ^{[1
]}

Wang, Han ^{[1
]}

Cheng, Hanchao ^{[1
]}

Hernandez, Jose G. ^{[1
]}

Bolm, Carsten ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 24期

关键词：

Iodine-Mediated; Hofmann-Loffler-Freytag reaction; sulfoximines; dihydroisothiazole oxides; C-H AMINATION; INTRAMOLECULAR FUNCTIONALIZATION; VISIBLE-LIGHT; RADICALS; CATALYSIS; BONDS;

D O I：

10.1002/adsc.201701178

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A Hofmann-Loffler-Freytag type cyclization reaction of S-aryl-S-phenylpropyl sulfoximines (and related derivatives) was developed. Using molecular iodine as the initiator under visible light a series of five-membered cyclic products was obtained in moderate to high yields. The approach represents a new strategy for the synthesis of dihydroisothiazole oxides and benzo[d] isothiazoles-1-oxides.

引用

页码：4274 / 4277

页数：4

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