Prostate-Specific Membrane Antigen-Targeted Imaging With [18F] DCFPyL in High-Grade Gliomas

被引：49
|
作者：
Fragomeni, Roberto Andres Salas [1 ]
Menke, Joshua R. [2 ]
Holdhoff, Matthias [3 ]
Ferrigno, Clare [3 ]
Laterra, John Joseph [3 ]
Solnes, Lilja B. [1 ]
Javadi, Mehrbod S. [1 ]
Szabo, Zsolt [1 ]
Pomper, Martin G. [1 ,3 ]
Rowe, Steven P. [1 ]
机构：
[1] Johns Hopkins Sch Med, Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA
[2] Johns Hopkins Sch Med, Dept Pathol, Baltimore, MD 21287 USA
[3] Johns Hopkins Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21287 USA
来源：
CLINICAL NUCLEAR MEDICINE | 2017年 / 42卷 / 10期
关键词：
glioblastoma; gliomas; MRI; PET/CT; primary brain tumor; prostate-specific membrane antigen; PSMA; EXPRESSION;
D O I：
10.1097/RLU.0000000000001769
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
High-grade gliomas (World Health Organization grade III-IV) are highly lethal primary brain tumors. Imaging modalities, including MRI and FDG PET, provide a limited ability to differentiate treatment effects (such as radiation necrosis) from recurrent or residual tumor. As the first step in validating the applicability of prostate-specific membrane antigen (PSMA)-targeted imaging in high-grade gliomas, we evaluated the ability of the PSMA-targeted small molecule [F]DCFPyL (2-(3-(1carboxy-5-(6-[F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid) to image high-grade gliomas in a series of 3 prospectively recruited patients. We found [F]DCFPyL binds PSMA in the neovasculature of glioblastoma multiforme and tumor cells of anaplastic astrocytoma.
引用
收藏
页码：E433 / E435
页数：3
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