Roles of PFKFB3 in cancer

被引：194
|
作者：
Shi, Linlin [1 ]
Pan, Hongming [1 ,2 ]
Liu, Zhen [1 ]
Xie, Jiansheng [2 ]
Han, Weidong [1 ,2 ]
机构：
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Med Oncol, Coll Med, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Inst Clin Sci, Sir Run Run Shaw Hosp, Lab Canc Biol,Coll Med, Hangzhou, Zhejiang, Peoples R China
来源：
SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2017年 / 2卷
基金：
中国国家自然科学基金;
关键词：
HEPATIC 6-PHOSPHOFRUCTO-2-KINASE FRUCTOSE-2,6-BISPHOSPHATASE; SUPPRESSES GLUCOSE-METABOLISM; ACTIVATED PROTEIN-KINASE; KEY GLYCOLYTIC ENZYME; STEM-CELLS; OXIDATIVE-PHOSPHORYLATION; FRUCTOSE 2,6-BISPHOSPHATE; CARBOHYDRATE-METABOLISM; TUMOR-CELLS; RISK-FACTOR;
D O I：
10.1038/sigtrans.2017.44
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The understanding of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFK-2/FBPase 3, PFKFB3) has advanced considerably since its initial identification in human macrophages in the mid-1990s. As a vital regulator of glycolysis, accumulating studies have suggested that PFKFB3 is associated with many aspects of cancer, including carcinogenesis, cancer cell proliferation, vessel aggressiveness, drug resistance and tumor microenvironment. In this review, we summarize current knowledge of PFKFB3 regulation by several signal pathways and its function in cancer development in different cell types in cancer tissues. Ubiquitous PFKFB3 has emerged as a potential target for anti-neoplastic therapy.
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页数：10
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