Interaction between morphine and lysine

被引：1
|
作者：
Nakai, S [1 ]
Yoneda, F [1 ]
机构：
[1] Fujimoto Pharmaceut Corp, Matsubara, Osaka 5808503, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 11期
关键词：
D O I：
10.1016/S0960-894X(01)00228-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The study by the molecular orbital theory displayed that morphine and lysine make two types of the interactions between them: type (A) by three hydrogen bondings and type (B) by one hydrogen bonding accompanied with a proton transfer. The stabilization energies were 45.3 and 34.9 kcal/mol for type (A) and type (B), respectively. The characters of these interactions are striking compared to the interactions of morphine with the other amino acids, suggesting that lysine is the binding point of morphine in the mu -opioid receptor. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：1383 / 1387
页数：5
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