Time to Initiation of Antiretroviral Therapy Among Patients With HIV-Associated Tuberculosis in Cape Town, South Africa

被引：22

作者：

Lawn, Stephen D. ^{[1
,2
]}

Campbell, Lucy ^{[3
,4
]}

Kaplan, Richard ^{[1
]}

Boulle, Andrew ^{[2
]}

Cornell, Morna ^{[4
]}

Kerschberger, Bernhard ^{[5
]}

Morrow, Carl ^{[1
]}

Little, Francesca ^{[3
]}

Egger, Matthias ^{[6
]}

Wood, Robin ^{[1
]}

机构：

[1] Univ Cape Town, Fac Hlth Sci, Inst Infect Dis & Mol Med, Desmond Tutu HIV Ctr, ZA-7925 Cape Town, South Africa

[2] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Clin Res, London WC1, England

[3] Univ Cape Town, Fac Sci, Dept Stat Sci, ZA-7925 Cape Town, South Africa

[4] Univ Cape Town, Fac Hlth Sci, Sch Publ Hlth & Family Med, Ctr Infect Dis Epidemiol & Res, ZA-7925 Cape Town, South Africa

[5] Med Sans Frontieres, Cape Town, South Africa

[6] Univ Bern, Inst Social & Prevent Med, Div Int & Environm Hlth, Bern, Switzerland

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2011年 / 57卷 / 02期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

Africa; antiretroviral; delay; timing; tuberculosis; IMMUNE RECONSTITUTION DISEASE; TREATMENT OUTCOMES; TREATMENT PROGRAM; RISK-FACTORS; KHAYELITSHA; MORTALITY; SURVIVAL; SERVICE; IMPACT; CARE;

D O I：

10.1097/QAI.0b013e3182199ee9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied the time interval between starting tuberculosis treatment and commencing antiretroviral treatment(ART) in HIV-infected patients (n = 1433; median CD4 count 71 cells permicroliter, interquartile range: 32-132) attending 3 South African township ART services between 2002 and 2008. The overall median delay was 2.66 months (interquartile range: 1.58-4.17). In adjusted analyses, delays varied between treatment sites but were shorter for patients with lower CD4 counts and those treated in more recent calendar years. During the most recent period (2007-2008), 4.7%, 19.7%, and 51.1% of patients started ART within 2, 4, and 8 weeks of tuberculosis treatment, respectively. Operational barriers must be tackled to permit further acceleration of ART initiation as recommended by 2010 WHO ART guidelines.

引用

页码：136 / 140

页数：5

共 50 条

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