Guanfacine for the treatment of attention deficit hyperactivity disorder in children and adolescents

被引：8

作者：

Rizzo, Renata ^{[1
]}

Martino, Davide ^{[2
,3
]}

机构：

[1] Univ Catania, Neuropsichiatria Infantile, Dipartimento Sci Med & Pediat, I-95123 Catania, Italy

[2] Kings Coll Hosp NHS Fdn Trust, Dept Neurol, London, England

[3] Queen Elizabeth Hosp, Lewisham & Greenwich NHS Trust, London, England

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2015年 / 15卷 / 04期

关键词：

alpha(2)-adrenoreceptor agonist; attention deficit hyperactivity disorder; guanfacine extended-release; guanfacine immediate-release; treatment; EXTENDED-RELEASE; DEFICIT/HYPERACTIVITY DISORDER; DOUBLE-BLIND; OPEN-LABEL; LONG-TERM; PHASE-I; ADHD; PHARMACOKINETICS; PSYCHOSTIMULANTS; NEUROBIOLOGY;

D O I：

10.1586/14737175.2015.1028370

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Guanfacine is an (2A)-adrenoreceptor agonist currently indicated for the treatment of attention deficit hyperactivity disorder (ADHD). This article reviews the chemistry, pharmacodynamics and pharmacokinetics of guanfacine, as well as the clinical trial literature on guanfacine for the treatment of ADHD in children and adolescents, mainly focusing on the use of guanfacine extended-release (GXR). Six already published prospective randomized controlled trials (RCTs) and one unpublished RCT study were identified for GXR in the treatment of ADHD. All RCTs trials showed superiority over placebo on the primary outcome measure. Guanfacine, especially XR, seems to be an effective and safe treatment option for ADHD in children and adolescents.

引用

页码：347 / 354

页数：8

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