Catalytic, asymmetric Mannich-type reactions of α-imino esters bearing readily removable substituents on nitrogen

被引：48
|
作者：
Nakamura, Y [1 ]
Matsubara, R [1 ]
Kiyohara, H [1 ]
Kobayashi, S [1 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 14期
关键词：
D O I：
10.1021/ol034717d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Catalytic, enantioselective Mannich-type reactions of alpha-imino esters bearing readily removable substituents on nitrogen are described. Several N-carbamate-protected alpha-imino esters, which are readily prepared from 2-bromoglycine esters using a polymer-supported amine, reacted with silicon enolates to afford the desired adducts in high yields with high enantioselectivity using a copper(II)-diamine complex. Easy deprotection of the product amine and transformation to free a-amino acid derivatives have also been demonstrated.
引用
收藏
页码：2481 / 2484
页数：4
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