Microwave-Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents

被引：6

作者：

McGown, Andrew ^{[1
]}

Ragazzon-Smith, Abby ^{[1
]}

Hadfield, John A. ^{[1
]}

Potgetier, Herman ^{[2
]}

Ragazzon, Patricia A. ^{[3
]}

机构：

[1] Univ Salford, Biomed Res Ctr, Environm & Life Sci, Salford, Lancs, England

[2] Manchester Metropolitan Univ, Sch Sci & Environm, Manchester, Lancs, England

[3] Keele Univ, Sch Pharm, Keele, Staffs, England

来源：

LETTERS IN ORGANIC CHEMISTRY | 2019年 / 16卷 / 01期

关键词：

Flavonoid; bis-flavonoid; green-chemistry; click-chemistry; microwave-assisted chemistry; anticancer; CLICK CHEMISTRY; PREVENTION; BLOOD;

D O I：

10.2174/1570178615666180621094529

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, we describe a microwave-based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4'-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 mu M. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

引用

页码：66 / 75

页数：10

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