One-Pot Synthesis of Chiral Nonracemic Amines

被引：7
|
作者：
Roe, Caroline [1 ]
Hobbs, Heather [2 ]
Stockman, Robert A. [1 ]
机构：
[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
[2] GlaxoSmithKline, Stevenage SG1 2NY, Herts, England
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 22期
基金：
英国工程与自然科学研究理事会;
关键词：
CATALYZED ASYMMETRIC ARYLATION; TRANSFER HYDROGENATION; STEREOSELECTIVE-SYNTHESIS; REDUCTIVE AMINATION; N-TOSYLARYLIMINES; CASCADE REACTIONS; IMINES; SULFINIMINES; REAGENTS; LIGAND;
D O I：
10.1021/jo201849j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
One-pot five-component reactions of oxathiazolidine-S-oxides with mesitylmagnesium bromide, lithium bis(trimethylsilyl)amide, aldehydes and Grignard reagents afford chiral nonracemic amines or sulfinamides in good yields and high stereoselectivities.
引用
收藏
页码：9452 / 9459
页数：8
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