Plasmid with Colistin Resistance Gene mcr-1 in Extended-Spectrum-β-Lactamase-Producing Escherichia coli Strains Isolated from Pig Slurry in Estonia

被引：34
|
作者：
Brauer, Age [1 ]
Telling, Kaidi [2 ]
Laht, Mailis [3 ]
Kalmus, Piret [4 ]
Lutsar, Irja [2 ]
Remm, Maido [1 ]
Kisand, Veljo [3 ]
Tenson, Tanel [3 ]
机构：
[1] Univ Tartu, Inst Mol & Cell Biol, Tartu, Estonia
[2] Univ Tartu, Inst Microbiol, Tartu, Estonia
[3] Univ Tartu, Inst Technol, Tartu, Estonia
[4] Estonian Univ Life Sci, Inst Vet Med & Anim Sci, Tartu, Estonia
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 11期
关键词：
CARBAPENEM-RESISTANT; HARBORING MCR-1; SEQUENCE;
D O I：
10.1128/AAC.00443-16
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A plasmid carrying the colistin resistance gene mcr-1 was isolated from a pig slurry sample in Estonia. The gene was present on a 33,311-bp plasmid of the IncX4 group. mcr-1 is the only antibiotic resistance gene on the plasmid, with the other genes mainly coding for proteins involved in conjugative DNA transfer (taxA, taxB, taxC, trbM, and the pilX operon). The plasmid pESTMCR was present in three phylogenetically very different Escherichia coli strains, suggesting that it has high potential for horizontal transfer.
引用
收藏
页码：6933 / 6936
页数：4
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