Pulmonary Oligometastases Treated by Stereotactic Body Radiation Therapy: A Nationwide Survey of 1,378 Patients

被引：21

作者：

Niibe, Yuzuru ^{[1
,2
]}

Yamamoto, Takaya ^{[3
]}

Onishi, Hiroshi ^{[4
]}

Yamashita, Hideomi ^{[5
]}

Katsui, Kuniaki ^{[6
]}

Matsumoto, Yasuo ^{[7
]}

Oh, Ryoong-Jin ^{[8
]}

Aoki, Masahiko ^{[9
]}

Shintani, Takashi ^{[10
]}

Yamada, Kazunari ^{[11
]}

Kobayashi, Mitsuru ^{[12
]}

Ozaki, Masatoki ^{[13
]}

Manabe, Yoshihiko ^{[14
]}

Yahara, Katsuya ^{[15
]}

Nishikawa, Atsushi ^{[16
]}

Kakuhara, Hisao ^{[17
]}

Yamamoto, Kentaro ^{[18
]}

Inoue, Tetsuya ^{[19
]}

Takada, Yu ^{[20
]}

Nagata, Kenji ^{[21
]}

Suzuki, Osamu ^{[22
]}

Terahara, Atsuro ^{[1
]}

Jingu, Keiichi ^{[3
]}

机构：

[1] Toho Univ, Dept Radiol, Omori Med Ctr, Tokyo, Japan

[2] Okayama Univ, Dept Primary Care & Med Educ, Okayama, Japan

[3] Tohoku Univ, Dept Radiat Oncol, Grad Sch Med, Sendai, Miyagi, Japan

[4] Univ Yamanashi, Dept Radiol, Kofu, Yamanashi, Japan

[5] Univ Tokyo, Dept Radiol, Tokyo, Japan

[6] Okayama Univ, Dept Proton Beam Therapy, Okayama, Japan

[7] Niigata Canc Ctr Hosp, Dept Radiat Oncol, Niigata, Japan

[8] Miyakojima IGRT Clin, Dept Radiat Oncol, Osaka, Japan

[9] Hirosaki Univ, Dept Radiol, Hirosaki, Aomori, Japan

[10] Kyoto Univ, Dept Radiat Oncol & Image Appl Therapy, Kyoto, Japan

[11] Keiyukai Sapporo Hosp, Dept Radiat Oncol, Sapporo, Hokkaido, Japan

[12] Seirei Mikatahara Gen Hosp, Dept Radiat Oncol, Shizuoka, Japan

[13] Fukuyama City Hosp, Dept Radiat Oncol, Hiroshima, Japan

[14] Shizuoka City Shimizu Hosp, Dept Radiat Oncol, Shizuoka, Japan

[15] Nagoya City Univ, Dept Radiol, Nagoya, Aichi, Japan

[16] Univ Occupat & Environm Hlth, Dept Radiol, Fukuoka, Japan

[17] Shikoku Canc Ctr, Dept Radiat Oncol, Matsuyama, Ehime, Japan

[18] Iwate Med Univ, Dept Radiol, Morioka, Iwate, Japan

[19] Self Def Forces Cent Hosp, Dept Radiol, Tokyo, Japan

[20] Dept Nagasaki Prefecture Shimabara Hosp, Nagasaki, Japan

[21] Hokkaido Univ Hosp, Dept Radiol, Sapporo, Hokkaido, Japan

[22] Juntendo Univ Hosp, Dept Radiol, Tokyo, Japan

来源：

ANTICANCER RESEARCH | 2020年 / 40卷 / 01期

关键词：

Pulmonary oligometastases; pulmonary oligo-recurrence; pulmonary sync-oligometastases; SBRT; nationwide study; OLIGO-RECURRENCE; RADIOTHERAPY; CANCER;

D O I：

10.21873/anticanres.13965

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: This study was performed to confirm the superior overall survival (OS) after pulmonary oligo-recurrence compared to pulmonary sync-oligometastases in a large nationwide study. Patients and Methods: Patients that met the following criteria were included: 1 to 5 lung-only metastases at the beginning of stereotactic body radiation therapy (SBRT) was performed between January 2004 and June 2015, and the biological effective dose (BED) of SBRT was 75 Gy or more. The parameters included in the analyses were age, gender, ECOG PS, primary lesion, pathology, oligoetastatic state, SBRT date, chemotherapy before SBRT, chemotherapy concurrent SBRT, chemotherapy after SBRT, maximum tumor diameter, number of metastases, field coplanarity, dose prescription, BED10, OTT of SBRT. Results: In total, 1,378 patients with 1,547 tumors were enrolled. Oligo-recurrence occurred in 1,016 patients, sync-oligometastases in 118, and unclassified oligometastases in 121. The three-year OS was 64.0% for oligorecurrence and 47.5% for sync-oligometastasis (p<0.001). In the multivariate analysis, the hazard ratio (HR) for sync-oligometastases versus oligo-recurrence was 1.601 (p=0.014). Adverse events of Grade 5 were occurred in 3 patients. Conclusion: This is the first nationwide to indicate that the OS of patients with pulmonary oligo-recurrence is better than that of patients with sync-oligometastases.

引用

页码：393 / 399

页数：7

共 50 条

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Niibe, Y.
Yamamoto, T.
Onishi, H.
Yamashita, H.
Katsui, K.
Matsumoto, Y.
Oh, R.
Aoki, M.
Shintani, T.
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