Multiple Sclerosis Therapy Consensus Group (MSTCG): position statement on disease-modifying therapies for multiple sclerosis (white paper)

被引：120

作者：

Wiendl, Heinz ^{[1
]}

Gold, Ralf ^{[2
]}

Berger, Thomas ^{[4
]}

Derfuss, Tobias ^{[5
]}

Linker, Ralf ^{[6
]}

Maurer, Mathias ^{[7
]}

Aktas, Orhan ^{[8
]}

Baum, Karl ^{[9
]}

Berghoff, Martin ^{[10
]}

Bittner, Stefan ^{[11
]}

Chan, Andrew ^{[12
]}

Czaplinski, Adam ^{[13
]}

Deisenhammer, Florian ^{[14
]}

Di Pauli, Franziska ^{[14
]}

Du Pasquier, Renaud ^{[15
]}

Enzinger, Christian ^{[16
]}

Fertl, Elisabeth ^{[17
]}

Gass, Achim ^{[18
]}

Gehring, Klaus ^{[19
]}

Gobbi, Claudio

Goebels, Norbert ^{[20
]}

Guger, Michael ^{[21
]}

Haghikia, Aiden ^{[22
]}

Hartung, Hans-Peter ^{[23
,24
]}

Heidenreich, Fedor ^{[25
]}

Hoffmann, Olaf ^{[26
,27
,28
]}

Kallmann, Boris ^{[29
]}

Kleinschnitz, Christoph ^{[30
]}

Klotz, Luisa ^{[31
]}

Leussink, Verena I. ^{[32
]}

Leutmezer, Fritz ^{[33
]}

Limmroth, Volker ^{[34
]}

Lunemann, Jan D. ^{[35
]}

Lutterotti, Andreas ^{[36
]}

Meuth, Sven G. ^{[37
]}

Meyding-Lamade, Uta ^{[38
]}

Platten, Michael ^{[39
]}

Rieckmann, Peter ^{[40
]}

Schmidt, Stephan ^{[41
]}

Tumani, Hayrettin ^{[42
]}

Weber, Frank ^{[43
]}

Weber, Martin S. ^{[44
]}

Zettl, Uwe K. ^{[45
]}

Ziemssen, Tjalf ^{[46
]}

Zipp, Frauke ^{[3
]}

机构：

[1] Univ Klinikum Munster, Klin Neurol, Inst Translate Neurol, Albert Schweitzer Campus 1,Gebaude A1, D-48149 Munster, Germany

[2] Klinikum Ruhr Univ Bochum, St Josef Hosp, Neurol, Gudrunstr 56, D-44791 Bochum, Germany

[3] Johannes Gutenberg Univ Mainz, Univ Med, Klin & Poliklin Neurol, Langenbeckstr 1, D-55131 Mainz, Germany

[4] Med Univ Wien, Univ Klin Neurol, Vienna, Austria

[5] Univ Spital Basel, Neurol Klin & Poliklin, Basel, Switzerland

[6] Univ Klinikum Regensburg, Klin Poliklin Neurol, Regensburg, Germany

[7] Klinikum Wurzburg Mitte gGmbH, Neurol & Neurol Fruhrehabil, Standort Juliusspital, Wurzburg, Germany

[8] Heinrich Heine Univ Dusseldorf, Neurol Klin, Dusseldorf, Germany

[9] Klin Hennigsdorf, Neurol, Hennigsdorf, Germany

[10] Univ Klinikum Giessen, Neurol, Giessen, Germany

[11] Johannes Gutenberg Univ Mainz, Univ Med Johannes Gutenberg, Klin Neurol, Mainz, Germany

[12] Univ Spital Bern, Inselspital, Neurol, Bern, Switzerland

[13] Bellevue Med Grp, Neurol FMH, Zurich, Switzerland

[14] Univ Klin Neurol, Innsbruck, Austria

[15] Univ Klin Neurol, Lausanne, Austria

[16] Med Univ Graz, Univ Klin Neurol, Graz, Austria

[17] Wiener Gesundheitsverbund, Neurol Abt, Vienna, Austria

[18] Univ Med Mannheim, Univ Heidelberg, Neurol Klin, Med Fak Mannheim, Mannheim, Germany

[19] Berufsverband Deutsch Nervenarzte BVDN, Neurozentrum Klosterforst, Itzehoe, Germany

[20] Univ Klinikum Dusseldorf, Klin Neurol, Dusseldorf, Germany

[21] Kepler Univ Klinikum, Klin Neurol 2, Linz, Austria

[22] Univ Klin Neurol, Magdeburg, Germany

[23] Heinrich Heine Univ Dusseldorf, Neurol Klin, Med Fak, Dusseldorf, Austria

[24] Med Univ Wien, Neurol Klin, Vienna, Austria

[25] Diakovere Krankenhaus, Henriettenstift, Klin Neurol & Klin Neurophysiol, Hannover, Germany

[26] Alexianer St Josefs Krankenhaus Potsdam, Neurol Klin, Potsdam, Germany

[27] Charite Univ Med Berlin, NeuroCure, Berlin, Germany

[28] Med Hsch Brandenburg Theodor Fontane, Neuruppin, Germany

[29] Multiple Sklerose Zentrum Bamberg, Kallmann Neurol, Bamberg, Germany

[30] Univ Klinikum Essen AoR, Klin Neurol, Essen, Germany

[31] Univ Klinikum Munter, Neurol Klin, Inst Translat Neurol, Munster, Germany

[32] MS Zentrum, Neurol Meerbusch, Meerbusch, Germany

[33] Univ Klin Neurol Wien, Neurol, Vienna, Austria

[34] Krankenhaus Koln, Klin Neurol, Cologne, Germany

[35] Univ Klinikum Munster, Klin Neurol, Inst Translat Neurol, Munster, Germany

[36] Univ Spital Zurich, Klin Neurol, Zurich, Switzerland

[37] Heinrich Heine Univ Dusseldorf, Neurol Klin, Dusseldorf, Germany

[38] Krankenhaus NW Frankfurt, Neurol, Frankfurt, Germany

[39] Heidelberg Univ, Univ Med Mannheim, Med Fak Mannheim, Neurol Klin, Mannheim, Germany

[40] Zentrum Klin Neuroplast, Fachklin Neurol, Med Pk, Bischofswiesen, Germany

[41] Johannes Hosp, Neurol, Gesundheitszentrum St, Bonn, Germany

[42] Akad Krankenhaus Univ Ulm, Fachklin Neurol Dietenbronn, Ulm, Germany

[43] Sana Kliniken, Neurol, Cham, Switzerland

[44] Univ Med Gottingen, Neurol Klin, Inst Neuropathol, Gottingen, Germany

[45] Klin Poliklin Neurol, Zentrum Nervenheilkunde, Univ Med Rostock, Rostock, Germany

[46] Carl Gustav Carus Tech Univ Dresden, Univ Klinikum, Klin & Poliklin Neurol, Dresden, Germany

来源：

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS | 2021年 / 14卷

关键词：

disease-modifying therapy; guideline; multiple sclerosis; treatment recommendation; STEM-CELL TRANSPLANTATION; PLACEBO-CONTROLLED TRIAL; 1ST DEMYELINATING EVENT; 5-YEAR FOLLOW-UP; INTERFERON BETA-1A; INTRAMUSCULAR INTERFERON; PHARMACOLOGICAL-TREATMENT; ECTRIMS/EAN GUIDELINE; CLINICALLY DEFINITE; ORAL CLADRIBINE;

D O I：

10.1177/17562864211039648

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis is a complex, autoimmune-mediated disease of the central nervous system characterized by inflammatory demyelination and axonal/neuronal damage. The approval of various disease-modifying therapies and our increased understanding of disease mechanisms and evolution in recent years have significantly changed the prognosis and course of the disease. This update of the Multiple Sclerosis Therapy Consensus Group treatment recommendation focuses on the most important recommendations for disease-modifying therapies of multiple sclerosis in 2021. Our recommendations are based on current scientific evidence and apply to those medications approved in wide parts of Europe, particularly German-speaking countries (Germany, Austria, and Switzerland).

引用

页数：39

共 50 条

[1] Multiple sclerosis treatment consensus group (MSTCG): position paper on disease-modifying treatment of multiple sclerosis 2021 (white paper)
Wiendl, Heinz
Gold, Ralf
Berger, Thomas
Derfuss, Tobias
Linker, Ralf
Maeurer, Mathias
Stangel, Martin
Aktas, Orhan
Baum, Karl
Berghoff, Martin
Bittner, Stefan
Chan, Andrew
Czaplinski, Adam
Deisenhammer, Florian
Di Pauli, Franziska
Du Pasquier, Renaud
Enzinger, Christian
Fertl, Elisabeth
Gass, Achim
Gehring, Klaus
Gobbi, Claudio
Goebels, Norbert
Guger, Michael
Haghikia, Aiden
Hartung, Hans-Peter
Heidenreich, Fedor
Hoffmann, Olaf
Hunter, Zoe R.
Kallmann, Boris
Kleinschnitz, Christoph
Klotz, Luisa
Leussink, Verena
Leutmezer, Fritz
Limmroth, Volker
Luenemann, Jan D.
Lutterotti, Andreas
Meuth, Sven G.
Meyding-Lamade, Uta
Platten, Michael
Rieckmann, Peter
Schmidt, Stephan
Tumani, Hayrettin
Weber, Martin S.
Weber, Frank
Zettl, Uwe K.
Ziemssen, Tjalf
Zipp, Frauke
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[5] The risk of infection in patients with multiple sclerosis treated with disease-modifying therapies: A Delphi consensus statement
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[6] International consensus statement on the use of disease-modifying agents in multiple sclerosis
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[7] Discontinuing disease-modifying multiple sclerosis therapies
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[8] Emerging multiple sclerosis disease-modifying therapies
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[9] Emerging Disease-Modifying Therapies in Multiple Sclerosis
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[10] Cost of disease-modifying therapies for multiple sclerosis
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