Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers

被引：22

作者：

Xie, Shangdan ^{[1
]}

Xia, Lu ^{[1
]}

Song, Yizuo ^{[1
]}

Liu, Hejing ^{[1
]}

Wang, Zhi-wei ^{[1
]}

Zhu, Xueqiong ^{[1
]}

机构：

[1] Wenzhou Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 2, Wenzhou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

关键词：

NEDD4L; ubiquitination; cancer; treatment; degradation; DOWN-REGULATION; POOR-PROGNOSIS; TUMOR-GROWTH; EXPRESSION; CATENIN; PROTEIN; CELLS; PROLIFERATION; EPIDEMIOLOGY; PATHOGENESIS;

D O I：

10.3389/fonc.2021.774648

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) is an E3 ubiquitin ligase that has been reported to participate in multiple cellular procedures by regulating of substrate ubiquitination and subsequent protein degradation. A great amount of evidence has demonstrated that NEDD4L mainly functions as a tumor suppressor in most cancer types, while it also acts as an oncogene in a few cancers. In this review, we summarize the potential role of NEDD4L in carcinogenesis and the related underlying molecular mechanism to improve our understanding of its functions in the tumorigenesis of human malignancies. Developing clinical drugs targeting NEDD4L could be a potential therapeutic strategy for cancer therapy in the future.

引用

页数：10

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