Adaptation of a strain of Plasmodium falciparum from Ghana to Aotus lemurinus griseimembra, A-nancymai, and A-vociferans monkeys

被引:10
|
作者
Sullivan, JS
Sullivan, JJ
Williams, A
Grady, KK
Bounngaseng, A
Huber, CS
Nace, D
Williams, T
Galland, GG
Barnwell, JW
Collins, WE
机构
[1] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA 30341 USA
[2] Ctr Dis Control & Prevent, Anim Resources Branch, Natl Ctr Infect Dis, Atlanta, GA 30341 USA
[3] Vet Affairs Med Ctr, Atlanta Res & Educ Fdn, Atlanta, GA 30033 USA
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关键词
D O I
10.4269/ajtmh.2003.69.593
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
A strain of Plasmodium falciparum from Ghana was adapted to Aotus lemurinus griseimembra, A. nancymai, and A. vociferans monkeys. Gametocytes in splenectomized A. nancymai were infective to Anopheles freeborni mosquitoes. Sporozoite transmission was accomplished in two splenectomized A. nancymai with prepatent periods of 22 and 25 days. The Ghana III/CDC strain of P. falciparum is susceptible to treatment with chloroquine and mefloquine.
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页码:593 / 600
页数:8
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