Novel synthesis of divergent aryl imidazoles from ketones involving copper-catalyzed α-amination and oxidative C-C bond cleavage

被引：8
|
作者：
Huang, Jiangkun [1 ,2 ]
Luo, Lan [1 ,2 ]
Xing, Naiguo [1 ,2 ]
Gu, Linghui [1 ,2 ]
Li, Chen [1 ,2 ]
Han, Qiao [1 ,2 ]
Zheng, Shilong [3 ,4 ]
He, Ling [1 ,2 ]
机构：
[1] Sichuan Univ, West China Sch Pharm, Key Lab DrugTargeting & Drug Delivery Syst, Sichuan Engn Lab Plant Sourced Drug,Educ Minist, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Sch Pharm, Sichuan Res Ctr Drug Precis Ind Technol, Dept Med Chem, Chengdu 610041, Sichuan, Peoples R China
[3] Xavier Univ Louisiana, Dept Chem, New Orleans, LA 70125 USA
[4] Xavier Univ Louisiana, RCMI Canc Res Ctr, New Orleans, LA 70125 USA
来源：
RSC ADVANCES | 2020年 / 10卷 / 23期
基金：
中国国家自然科学基金;
关键词：
INDOLEAMINE 2,3-DIOXYGENASE; OXIME ACETATES; LIGANDS; METHYL; ACTIVATION; COMPLEXES; CHEMISTRY; MILD; INHIBITORS; AMIDATION;
D O I：
10.1039/d0ra01408g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A one-pot synthesis, initiated by a copper salt with inorganic (NH4)(2)CO3 as the nitrogen source, forms divergent aryl imidazole derivatives from ketones via alpha-amination and oxidative C-C bond cleavage reactions. The approach provides a simple and rapid synthesis of imidazole derivatives and has certain versatility.
引用
收藏
页码：13815 / 13819
页数：5
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